ArticleResearch in pharmaceutical sciences2012
Effects of various penetration enhancers on percutaneous absorption of piroxicam from emulgels.
Article in Research in pharmaceutical sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- Effect of Transcutol P on Percutaneous Absorption of Gel Containing Pure Synthetic Caffeine or Plant-Extracted Natural Caffeine.Dermatology research and practice · 2026Article
- Emulgel: A Cutting Edge Approach for Topical Drug Delivery System.Current drug research reviews · 2025Review
- Skin Penetration and Permeation Properties of TranscutolAAPS PharmSciTech · 2024Review
- Artemisinin emulgel ameliorates cartilage degradation in knee osteoarthritis:Therapeutic delivery · 2024Article
- Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery.Heliyon · 2022Review
- Effects of various penetration enhancers on penetration of aminophylline through shed snake skin.Jundishapur journal of natural pharmaceutical products · 2014Article
- In vitro and in vivo assessment of piroxicam incorporated Aloe vera transgel.International journal of pharmaceutical investigation · 2013Article
- The potent in vitro skin permeation of archaeosome made from lipids extracted of Sulfolobus acidocaldarius.Archaea (Vancouver, B.C.) · 2013Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A suitable emulgel formulation of piroxicam was prepared and its percutaneous permeation was investigated using Wistar rat skin and diffusion cell technique. The concentrations of the drug in receptor phase of diffusion cells were measured using HPLC method. The effect of three types of penetration enhancers (Myrj 52, cineol and Transcutol P) with different concentrations on transdermal permeation of the drug was also evaluated. Flux, Kp and enhancement ratios (ERs) of piroxicam in the presence of enhancers was measured and compared with emulgel base alone and simple commercial gel. The results showed a significant enhancement in the flux from emulgel base compared to hydroalcoholic gel formulation (9.91 folds over simple gel). The highest enhancement ratio (ER=3.11) was observed for Myrj 52 at the concentration of 0.25%. Higher concentrations of Myrj 52did not show any enhancement in the drug flux due to micelle formation and solubilization of the drug by micelles. The increase in solubility, in turn, increases the saturated concentration and reduces the thermodynamic activity of the drug. Transcutol(®) P with concentrations higher than 0.25% w/w showed burst transportation of the drug through the skin. All concentrations of cineol and Transcutol did not show any enhancing effects over emulgel base alone (ER <1).
Indexed as
Identifiers
23248673PMC3523414W2151735370What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.