ArticleFrontiers in genetics2012
MicroRNA: A Bridge from H. pylori Infection to Gastritis and Gastric Cancer Development.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Network analysis of H. pylori effect on AGS human gastric adenocarcinoma cells gene expression profile.Gastroenterology and hepatology from bed to bench · 2024Article
- Review
- Expression analysis of miRNA-155 level inIranian journal of microbiology · 2022Article
- Differential Expression of Tissular miRNA-155 in Pediatric Gastritis.Journal of clinical medicine · 2022Article
- Prediction of Blood miRNA-mRNA Regulatory Network in Gastric Cancer.Reports of biochemistry & molecular biology · 2021Article
- MicroRNA Modulation of Host Immune Response and Inflammation Triggered byInternational journal of molecular sciences · 2021Review
- Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review).Journal of clinical medicine · 2020Review
- Reversal of the Methylation-Associated Regulation of miR-200a/b byGut and liver · 2020Article
- STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects.Biology · 2020Review
- Decrease in MiR-148a Expression During Initiation of Chief Cell Transdifferentiation.Cellular and molecular gastroenterology and hepatology · 2020Article
- Article
- Treatment ofWorld journal of gastroenterology · 2018Review
- Upregulation of miR-222 in both Helicobacter pylori- infected and noninfected gastric cancer patients.Journal of genetics · 2016Article
- The Effect of MicroRNA-375 Overexpression, an Inhibitor ofJundishapur journal of microbiology · 2016Article
- Article
- hsa-miR-29c and hsa-miR-135b differential expression as potential biomarker of gastric carcinogenesis.World journal of gastroenterology · 2016Article
- Circulating MicroRNAs: Potential and Emerging Biomarkers for Diagnosis of Human Infectious Diseases.Frontiers in microbiology · 2016Review
- Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions.World journal of clinical oncology · 2015Review
- Review
- MiR-361-5p inhibits colorectal and gastric cancer growth and metastasis by targeting staphylococcal nuclease domain containing-1.Oncotarget · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori (H. pylori) infection is a recognized risk factor for gastric cancer. The disease is one of the most common in the world and explains for a significant number of cancer cases and cancer-associated deaths worldwide. H. pylori infection induces huge array of responses at the gastric epithelial cells and the immune system, inducing both pro- and anti-inflammatory molecules that are intended to either perpetuate or control the infection. Despite the strong immune response, the infection is not cleared and can persist mostly without causing major significant discomfort in the human host. Among the mediators induced in response to the infection, microRNA (miRNA) have the potential to play a major impact on the outcome of the bacteria-host interaction. These miRNA are small 18-24 nucleotide long nucleotide molecules that can interact with mRNA molecules and block their translation into proteins or induce their degradation. Many efforts have been put into the generation of miRNA profiles and their role in gastric cancer. This has led to the identification of miRNA associated with promoting the inflammatory response initiated by the H. pylori infection, increasing the malignant progression of the gastric epithelium, and enhancing the invasiveness and migratory capacity of cancer cells. However, at the same time, several miRNA have been associated with events that are totally opposite, leading to reduced inflammation, inhibition of malignancy and increased apoptosis of transformed cells. In summary, as it is in many other examples, the role played by miRNA in gastric cancer is the results of a delicate balance between pro- and anti-cancer miRNA, and this balance is modified by the interaction of many players, many of which are still waiting to be discovered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.