Evidence map›Paper›PMID 23248603›Full record

ArticleFrontiers in physiology2012

Modulation of myocardial contraction by peroxynitrite.

Mark J Kohr, Steve R Roof, Jay L Zweier, Mark T Ziolo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Circulation. Heart failure · 2017
    Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mark J KohrDepartment of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University Columbus, OH, USA ; Division of Cardiovascular Pathology, Department of Pathology, Johns Hopkins University Baltimore, MD, USA.
Steve R Roof
Jay L Zweier
Mark T Ziolo
The Ohio State University · USJohns Hopkins University · US

Funding

Stat3 in Post-Ischemic Myocardial InflammationP01HL065608 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BECKER, LEWIS C · 2000 to 2011
$22.0M
OXYGEN RADICALS AND NITRIC OXIDE IN POSTISCHEMIC INJURYR01HL063744 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2000 to 2009
$5.2M
MEASURE OF FREE RADICAL GENERATION IN HEARTR01HL038324 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 1992 to 2010
$3.5M
NOS1/NOS3 Functional Effects on Cardiac Myocyte FunctionR01HL079283 · NHLBI · OHIO STATE UNIVERSITY · PI ZIOLO, MARK T · 2006 to 2010
$1.8M
Nitric oxide signaling in healthy and diseased cardiac myocytesK02HL094692 · NHLBI · OHIO STATE UNIVERSITY · PI ZIOLO, MARK T · 2009 to 2013
$521k
NHLBI NIH HHS K02 HL094692NHLBI NIH HHS P01 HL065608NHLBI NIH HHS R01 HL038324NHLBI NIH HHS R01 HL063744NHLBI NIH HHS R01 HL079283
6 · The paper itself

Abstract

Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca(2+) handling, proposed signaling pathways, and protein end-targets.

Indexed as

Ca2+cAMP-dependent protein kinasemyocytenitric oxide synthaseperoxynitriteprotein phosphatase 2a

Identifiers

PMID23248603
PMCPMC3520483
OpenAlexW2115258969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.