ArticleFrontiers in physiology2012
The multiple roles of phosphate in muscle fatigue.
Article in Frontiers in physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- No ergogeniceffect of β-alanine on repeated sprint ability: a systematic review and multilevel meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- Exercise with fasting or isotonic drink? A randomized controlled trial in youth elite basketball players.Journal of the International Society of Sports Nutrition · 2025Trial
- Trial
- Patient-Reported Outcomes from a Randomized, Active-Controlled, Open-Label, Phase 3 Trial of Burosumab Versus Conventional Therapy in Children with X-Linked Hypophosphatemia.Calcified tissue international · 2021Trial
- Does Post-Activation Performance Enhancement Occur During the Bench Press Exercise under Blood Flow Restriction?International journal of environmental research and public health · 2020Trial
- Delaying task failure in high-intensity exercise: a Pi-afferent-effort framework for targeted sports nutrition.Journal of the International Society of Sports Nutrition · 2026Review
- Interplay between store-operated calcium entry and mitochondrial phosphate handling modulates force and fatigue during exercise.The Journal of physiology · 2026Article
- Altered Skeletal Muscle Phosphate Metabolism After Muscle Damage Is Associated With Elevated Effort Perception During Exercise in Humans.Scandinavian journal of medicine & science in sports · 2026Article
- Differences in circulatory dynamics and skeletal muscle blood flow during exercise between post-dialysis and non-dialysis days in hemodialysis patients.International urology and nephrology · 2026Article
- The efficacy and physiological bases of small muscle mass exercise in health and disease.Experimental physiology · 2026Review
- Differential effects of local and general fatigue on brain network efficiency, corticospinal and neuromuscular excitability.Journal of exercise science and fitness · 2026Article
- Article
- Enhancing exercise performance and recovery through sodium bicarbonate supplementation: introducing the ingestion recovery framework.European journal of applied physiology · 2024Review
- Skeletal Muscle Injury in Chronic Kidney Disease-From Histologic Changes to Molecular Mechanisms and to Novel Therapies.International journal of molecular sciences · 2024Review
- Disuse-Induced Muscle Fatigue: Facts and Assumptions.International journal of molecular sciences · 2024Review
- Utilizing the RPE-Clamp model to examine interactions among factors associated with perceived fatigability and performance fatigability in women and men.European journal of applied physiology · 2023Article
- The Effects of Anchor Schemes on Performance Fatigability, Neuromuscular Responses and the Perceived Sensations That Contributed to Task Termination.Journal of functional morphology and kinesiology · 2023Article
- Environmental-related variation of stoichiometric traits in body and organs of non-native sailfin catfishesEcology and evolution · 2022Article
- Effect of Six-Week Speed Endurance Training on Peripheral Fatigue.International journal of environmental research and public health · 2022Article
- Perceived mental strain dissociates from perceived physical strain during relative intensity submaximal exercise on ascent from low to high altitude.Physiological reports · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle fatigue is the decline in performance of muscles observed during periods of intense activity. ATP consumption exceeds production during intense activity and there are multiple changes in intracellular metabolites which may contribute to the changes in crossbridge activity. It is also well-established that a reduction in activation, either through action potential changes or reduction in Ca(2+) release from the sarcoplasmic reticulum (SR), makes an additional contribution to fatigue. In this review we focus on the role of intracellular inorganic phosphate (P(i)) whose concentration can increase rapidly from around 5-30 mM during intense fatigue. Studies from skinned muscle fibers show that these changes substantially impair myofibrillar performance although the effects are strongly temperature dependent. Increased P(i) can also cause reduced Ca(2+) release from the SR and may therefore contribute to the reduced activation. In a recent study, we have measured both P(i) and Ca(2+) release in a blood-perfused mammalian preparation and the results from this preparation allows us to test the extent to which the combined effects of P(i) and Ca(2+) changes may contribute to fatigue.
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Registered trials
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