ArticleFrontiers in neuroscience2012
Systematic Error in Hippocampal Volume Asymmetry Measurement is Minimal with a Manual Segmentation Protocol.
Article in Frontiers in neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Evaluation of deep learning models for segmentation of hippocampus volumes from MRI images in Alzheimer's disease.Scientific reports · 2026Article
- Filling in the gap: Hippocampal CA1 neuronal counts and volumes in female cognitive controls.Neurobiology of disease · 2025Article
- Morphological characterization of the hippocampus: a first database in Ecuador.Frontiers in human neuroscience · 2024Article
- Morphometric and microstructural characteristics of hippocampal subfields in mesial temporal lobe epilepsy and their correlates with mnemonic discrimination.Frontiers in neurology · 2023Article
- Effect of Gender on Development of Hippocampal Subregions From Childhood to Adulthood.Frontiers in human neuroscience · 2020Article
- Sexual Dimorphism and Hemispheric Asymmetry of Hippocampal Volumetric Integrity in Normal Aging and Alzheimer Disease.AJNR. American journal of neuroradiology · 2019Article
- Epigenetic modulation during hippocampal development.Biomedical reports · 2018Review
- Hippocampal subfield segmentation in temporal lobe epilepsy: Relation to outcomes.Acta neurologica Scandinavica · 2018Article
- MRI characterization of temporal lobe epilepsy using rapidly measurable spatial indices with hemisphere asymmetries and gender features.Neuroradiology · 2015Article
- Mesial Temporal Sclerosis: Accuracy of NeuroQuant versus Neuroradiologist.AJNR. American journal of neuroradiology · 2015Article
- Why looking at the whole hippocampus is not enough-a critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer's disease diagnosis.Frontiers in cellular neuroscience · 2014Review
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4 authors.
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Abstract
Hemispheric asymmetry of hippocampal volume is a common finding that has biological relevance, including associations with dementia and cognitive performance. However, a recent study has reported the possibility of systematic error in measurements of hippocampal asymmetry by magnetic resonance volumetry. We manually traced the volumes of the anterior and posterior hippocampus in 40 healthy people to measure systematic error related to image orientation. We found a bias due to the side of the screen on which the hippocampus was viewed, such that hippocampal volume was larger when traced on the left side of the screen than when traced on the right (p = 0.05). However, this bias was smaller than the anatomical right > left asymmetry of the anterior hippocampus. We found right > left asymmetry of hippocampal volume regardless of image presentation (radiological versus neurological). We conclude that manual segmentation protocols can minimize the effect of image orientation in the study of hippocampal volume asymmetry, but our confirmation that such bias exists suggests strategies to avoid it in future studies.
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