ArticleJournal of oral and maxillofacial pathology : JOMFP2012
VEGF: A critical driver for angiogenesis and subsequent tumor growth: An IHC study.
Article in Journal of oral and maxillofacial pathology : JOMFP, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
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- Immunohistochemical Expression of VEGF and Microvessel Density (CD 34) in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma: Original Research.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Extracellular vesicle-bound VEGF in oral squamous cell carcinoma and its role in resistance to Bevacizumab Therapy.Cancer cell international · 2024Article
- High-fat-diet-induced obesity promotes simultaneous progression of lung cancer and atherosclerosis in apolipoprotein E-knockout mice.Cancer innovation · 2024Article
- Oral Pyogenic Granuloma: A Narrative Review.International journal of molecular sciences · 2023Review
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- LOX-1 and cancer: an indissoluble liaison.Cancer gene therapy · 2021Review
- Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound-guided needle biopsy specimens of prostate adenocarcinoma.Molecular and clinical oncology · 2021Article
- Urine LOX-1 and Volatilome as Promising Tools towards the Early Detection of Renal Cancer.Cancers · 2021Article
- Novel Pathways for Targeting Tumor Angiogenesis in Metastatic Breast Cancer.Frontiers in oncology · 2021Review
- Preliminary Post-Mortem COVID-19 Evidence of Endothelial Injury and Factor VIII Hyperexpression.Diagnostics (Basel, Switzerland) · 2020Article
- Gelam honey promotes ex vivo corneal fibroblasts wound healing.Cytotechnology · 2019Article
- Targeting LOX-1 Inhibits Colorectal Cancer Metastasis in an Animal Model.Frontiers in oncology · 2019Article
- Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma - An Insight into Pathogenesis.Journal of clinical and diagnostic research : JCDR · 2017Article
- Gelam honey potentiates ex vivo corneal keratocytes proliferation with desirable phenotype expression.BMC complementary and alternative medicine · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTumors require blood supply for their growth and dissemination. It is a well accepted paradigm that tumors recruit new blood vessels from the existing circulation (angiogenesis) and this participates in tumor invasion and metastasis. Studies in the literature provide evidence for expression of Vascular Endothelial Growth Factor (VEGF) by the tumor for neo-angiogenesis, which is not only required for the tumor growth but also its metastasis. Based on the literary evidences we carried out an Immuno-Histochemical (IHC) study for VEGF in Oral Squamous Cell Carcinoma (OSCC) tissues to provide a strong link between the factor and oral cancer.
aimTo analyze the expression of VEGF in OSCC tissues of different histological grades, clinical sizes and lymph node status and to use this as an indicator for disease progression by helping in delineating a risk population, that may benefit from an attractive adjuvant therapeutic strategy for OSCC. SETTINGS AND
designStudies published from 1990 till 2010 have only seen the association of VEGF with tumor angiogenesis and its possible role in metastasis. This is the first study that takes into account the clinical status of the lymph nodes and VEGF expressivity in a sample size of 30 cases. MATERIALS AND
methods30 oral squamous cell carcinoma tissue slides were stained using Hematoxylin and Eosin stain (to confirm the diagnosis) and immunohistochemically using VEGF antibody. IHC stained slides were thereafter evaluated for the positivity and intensity. STATISTICAL ANALYSIS: The result was subjected to statistical analysis using Chi-square test RESULTS AND
conclusionVEGF positivity was seen in approximately. 90% of cases which was independent of histological grade of OSCC. However the intensity increased with the clinical size of cancer and from palpable lymph node to a tender and hard lymph node.
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