ArticleDiabetes care2013
Presence of macroalbuminuria predicts severe hypoglycemia in patients with type 2 diabetes: a 10-year follow-up study.
Article in Diabetes care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- Exenatide and Renal Outcomes in Patients with Type 2 Diabetes and Diabetic Kidney Disease.American journal of nephrology · 2020Trial
- Risk factors for kidney disorders in patients with type 2 diabetes at high cardiovascular risk: An exploratory analysis (DEVOTE 12).Diabetes & vascular disease researchTrial
- 6. Glycemic Goals, Hypoglycemia, and Hyperglycemic Crises: Standards of Care in Diabetes-2026.Diabetes care · 2026Review
- Hypoglycaemia and its associations with diabetes and age-related factors in older home-dwelling people with diabetes.BMC geriatrics · 2025Observational
- Perception of hyper-/hypoglycemia and its related factors in type 2 diabetes: a continuous glucose monitoring-based prospective observational study.Diabetology international · 2025Article
- 6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes-2025.Diabetes care · 2025Review
- Some patients with type 2 diabetes may benefit from intensive glycaemic and blood pressure control: A post-hoc machine learning analysis of ACCORD trial data.Diabetes, obesity & metabolism · 2024Article
- 6. Glycemic Goals and Hypoglycemia: Standards of Care in Diabetes-2024.Diabetes care · 2024Review
- High number of hypoglycaemic episodes identified by CGM among home-dwelling older people with diabetes: an observational study in Norway.BMC endocrine disorders · 2023Observational
- The association between fasting plasma glucose variability and incident eGFR decline: evidence from two cohort studies.BMC public health · 2023Article
- 4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes-2023.Diabetes care · 2023Review
- Impaired awareness of hypoglycaemia in women with type 1 diabetes in pregnancy: Hypoglycaemia fear, glycaemic and pregnancy outcomes.Diabetic medicine : a journal of the British Diabetic Association · 2022Article
- External validation and clinical application of the predictive model for severe hypoglycemia.Frontiers in endocrinology · 2022Article
- 4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes-2022.Diabetes care · 2022Review
- Clinical outcomes in high-hypoglycaemia-risk patients with type 2 diabetes switching to insulin glargine 300 U/mL versus a first-generation basal insulin analogue in the United States : Results from the DELIVER High Risk real-world study.Endocrinology, diabetes & metabolism · 2022Observational
- Association between hemoglobin A1c variability and hypoglycemia-related hospitalizations in veterans with diabetes mellitus.BMJ open diabetes research & care · 2021Article
- Incidence rate and patient characteristics of severe hypoglycemia in treated type 2 diabetes mellitus patients in Japan: Retrospective Diagnosis Procedure Combination database analysis.Journal of diabetes investigation · 2018Article
- Risk Factors for Severe Hypoglycemia in Black and White Adults With Diabetes: The Atherosclerosis Risk in Communities (ARIC) Study.Diabetes care · 2017Article
- Risk factors for unstable blood glucose level: integrative review of the risk factors related to the nursing diagnosis.Revista latino-americana de enfermagem · 2017Review
- Epidemiology and outcomes of hypoglycemia in patients with advanced diabetic kidney disease on dialysis: A national cohort study.PloS one · 2017Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe investigated the factors that might influence the development of severe hypoglycemia in patients with type 2 diabetes. RESEARCH DESIGN AND
methodsFrom January 2000 to December 2002, patients with type 2 diabetes aged 25-75 years without chronic kidney disease (estimated glomerular filtration rate ≥60 mL/min/1.73 m(2)) were consecutively recruited (n = 1,217) and followed-up in January 2011 and May 2012. Severe hypoglycemia (SH) was defined as an event requiring the assistance of another person to actively administer glucose, hospitalization, or medical care in an emergency department. We used Cox proportional hazard regression analysis to test the association between SH episodes and potential explanatory variables.
resultsAfter a median 10.4 years of follow-up, 111 (12.6%) patients experienced 140 episodes of SH, and the incidence was 1.55 per 100 patient-years. Mean age and duration of diabetes were 55.3 ± 9.8 and 9.8 ± 6.5 years, respectively. The incidence of SH events was higher in older patients (P < 0.001), in those with a longer duration of diabetes (P < 0.001), in those who used insulin (P < 0.001) and sulfonylurea (P = 0.003), and in those who had macroalbuminuria (P < 0.001) at baseline. Cox hazard regression analysis revealed that SH was associated with longer duration of diabetes and the presence of macroalbuminuria (normoalbuminuria versus macroalbuminuria: hazard ratio, 2.52; 95% CI 1.31-4.84; P = 0.006).
conclusionsThe development of SH was independently associated with duration of diabetes and presence of macroalbuminuria, even with normal renal function in patients with type 2 diabetes.
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