ReviewSurgical and radiologic anatomy : SRA2013
The circumventricular organs of the brain: conspicuity on clinical 3T MRI and a review of functional anatomy.
Review in Surgical and radiologic anatomy : SRA, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 46 citations in OpenAlex.
- Permeability of the windows of the brain: feasibility of dynamic contrast-enhanced MRI of the circumventricular organs.Fluids and barriers of the CNS · 2020Trial
- Anatomy and Microsurgical Anatomy of the Pineal Region.Advances and technical standards in neurosurgery · 2026Review
- Unmasking the Area Postrema on MRI: Utility of 3D FLAIR, 3D-T2, and 3D-DIR Sequences in a Case-Control Study.Journal of imaging · 2025Article
- Breaking boundaries: role of the brain barriers in metastatic process.Fluids and barriers of the CNS · 2025Review
- Pediatric pineal region masses: a single-center experience over 25 years.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023Article
- Atavistic and vestigial anatomical structures in the head, neck, and spine: an overview.Anatomical science international · 2023Review
- Contrast Enhancement of the Normal Infundibular Recess Using Heavily T2-weighted 3D FLAIR.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2022Article
- Ependymal cells and neurodegenerative disease: outcomes of compromised ependymal barrier function.Brain communications · 2022Review
- Mass-spectrometry analysis of the human pineal proteome during night and day and in autism.Journal of pineal research · 2021Article
- Central Effects of Beta-Blockers May Be Due to Nitric Oxide and Hydrogen Peroxide Release Independently of Their Ability to Cross the Blood-Brain Barrier.Frontiers in neuroscience · 2019Article
- Circumventricular organs of human brain visualized on post-contrast 3D fluid-attenuated inversion recovery imaging.Neuroradiology · 2018Article
- Appearance of the Organum Vasculosum of the Lamina Terminalis on Contrast-enhanced MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2018Article
- The tuber cinereum as a circumventricular organ: an anatomical study using magnetic resonance imaging.Surgical and radiologic anatomy : SRA · 2017Article
- The suprapineal recess of the third ventricle: an anatomic study with magnetic resonance imaging.Surgical and radiologic anatomy : SRA · 2017Article
- Pseudo-intraventricular hemorrhage from a deep calcarine fissure.Surgical and radiologic anatomy : SRA · 2014Article
- Intranasal administration of oxytocin: behavioral and clinical effects, a review.Neuroscience and biobehavioral reviews · 2013Article
- Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe circumventricular organs (CVOs) occupy seven midline locations around the ventricles. They contain specialized ependymal cells called tanycytes and have an incomplete blood-brain barrier (BBB). We hypothesized that appearances of the lesser known CVOs on contrast-enhanced MRI might lead to confusion in image interpretation whereby they might be mistaken for pathology-related abnormal contrast enhancement. We therefore assessed the normal appearances and prevalence of contrast enhancement of the CVOs on routine clinical brain MRI and reviewed the functional anatomy of the CVOs.
methodsWe retrospectively reviewed sagittal and coronal pre- and post-contrast T1-weighted brain 3T MR images in 100 adult patients with normal findings. We assessed the presence of the median eminence (ME), neurohypophysis (NH), pineal gland (PG), subforniceal organ (SFO), organum vasculosum of the lamina terminalis (OVLT), subcommissural organ (SCO), and the area postrema (AP).
resultsThe frequency of contrast enhancement of the seven CVOs was as follows: ME in 100 %, NH in 96 %, PG in 84 %, SFO in 1 %, OVLT in 34 %, SCO in 0 %, and AP in 2 %.
conclusionsThe main CVOs (ME, NH, and PG) are well known and appreciated on brain imaging. However, there is a little awareness of the minor CVOs among neuroimagers. This is the first study of contrast enhancement prevalence of the SF, OV, SC, and AP on brain MRI. All the latter are small, faint, rarely visualized, and therefore not likely to cause misinterpretation with significant sources of pathology that cause breakdown of the BBB, such as tumor or inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.