ReviewNature reviews. Rheumatology2013
Tackling obesity in knee osteoarthritis.
Review in Nature reviews. Rheumatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 1 synthesis or guideline pooled it, 171 citations in OpenAlex.
- Association of osteoarthritis and circulating adiponectin levels: a systematic review and meta-analysis.Lipids in health and disease · 2018Pooled it
- The role of thermal balneotherapy in the treatment of obese patient with knee osteoarthritis.International journal of biometeorology · 2018Trial
- Acute Feasibility of Neuromuscular Electrical Stimulation in Severely Obese Patients with Obstructive Sleep Apnea Syndrome: A Pilot Study.BioMed research international · 2017Trial
- Osteoarthritis: molecular pathogenesis and potential therapeutic options.Signal transduction and targeted therapy · 2026Review
- Type 2 diabetes is not associated with excess risk of periprosthetic joint infection in obese patients undergoing total hip arthroplasty.BMC musculoskeletal disorders · 2026Article
- GLP-1 receptor agonists in obesity-related knee osteoarthritis: from weight loss to therapeutic pathway reconstruction.Frontiers in pharmacology · 2026Review
- Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Elevated Contact Stresses Compromise Activity-Mediated Cartilage Rehydration but not Lubrication.Annals of biomedical engineering · 2025Article
- A protocol to assess the Knee cartilage thickness in healthy older adults and analyze its correlation with patient-reported outcomes.MethodsX · 2025Article
- Patients with Higher Pulse Wave Velocity Are More Likely to Develop a More Severe Form of Knee Osteoarthritis: Implications for Cardiovascular Risk.Biomedicines · 2025Article
- The non-linear relationships between fat mass and lean body mass with arthritis.Lipids in health and disease · 2025Article
- Deep Learning for Automatic Knee Osteoarthritis Severity Grading and Classification.Indian journal of orthopaedics · 2024Article
- The role of obesity and adipose tissue dysfunction in osteoarthritis pain.Nature reviews. Rheumatology · 2024Review
- The dual amylin and calcitonin receptor agonist KBP-336 elicits a unique combination of weight loss, antinociception and bone protection - a novel disease-modifying osteoarthritis drug.Arthritis research & therapy · 2024Article
- Predictors of postoperative hospital length of stay after total knee arthroplasty.Singapore medical journal · 2024Article
- Metabolic syndrome increases osteoarthritis risk: findings from the UK Biobank prospective cohort study.BMC public health · 2024Article
- Ensemble deep-learning networks for automated osteoarthritis grading in knee X-ray images.Scientific reports · 2023Article
- Association of smoking with cartilage loss of knee osteoarthritis: data from two longitudinal cohorts.BMC musculoskeletal disorders · 2023Article
- Development of a nomogram prediction model for gait speed trajectories in persons with knee osteoarthritis.Scientific reports · 2023Article
- Investigation of the existence of and a block technique for the inferior lateral genicular nerve: cadaveric study.The Korean journal of pain · 2023Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity and knee osteoarthritis (OA), two of the most common chronic diseases, are often comorbid. Obesity increases the risk of knee OA by a variety of mechanisms, such as increased joint loading and changes in body composition, with detrimental effects related to metainflammation and behavioural factors, including diminished physical activity and subsequent loss of protective muscle strength. These complex interactions present a challenge to the managing physician. The risk of knee OA related to weight gain and obesity begins from an early age. Weight loss reduces the risk of incident knee OA, and, in established disease, reduces symptoms, improves function and is likely to reduce disease progression. We review strategies to facilitate weight loss, with particular reference to their application in people with knee OA. Although knee OA presents intrinsic barriers to weight management, weight loss is possible at all stages of disease. Exercise or muscle strengthening are desirable for general health and to improve function, but are not essential to achieve weight loss and a successful symptomatic result. The degree of weight loss required to achieve benefit might be greater with increasing disease severity. Finally, we outline the need for a societal approach to tackle obesity-related OA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.