ArticleLearning & memory (Cold Spring Harbor, N.Y.)2012
Significance of the centrally expressed TRP channel painless in Drosophila courtship memory.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- TRPA1 for Butterfly Eyespot Formation.International journal of molecular sciences · 2026Article
- Review
- Review
- Circadian Neuropeptide-Expressing Clock Neurons as Regulators of Long-Term Memory: Molecular and Cellular Perspectives.Frontiers in molecular neuroscience · 2022Review
- Article
- Regulation ofFrontiers in neuroscience · 2021Article
- Environmental Light Is Required for Maintenance of Long-Term Memory inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Modulation of innate and learned sexual behaviors by the TRP channel Painless expressed in the fruit fly brain: behavioral genetic analysis and its implications.Frontiers in behavioral neuroscience · 2014Review
- Insulin-producing cells regulate the sexual receptivity through the painless TRP channel in Drosophila virgin females.PloS one · 2014Article
- The smell of love in Drosophila.Frontiers in physiology · 2013Article
- A novel role for ecdysone in Drosophila conditioned behavior: linking GPCR-mediated non-canonical steroid action to cAMP signaling in the adult brain.PLoS genetics · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Considerable evidence has demonstrated that transient receptor potential (TRP) channels play vital roles in sensory neurons, mediating responses to various environmental stimuli. In contrast, relatively little is known about how TRP channels exert their effects in the central nervous system to control complex behaviors. This is also true for the Drosophila TRP channel encoded by painless (pain). The Pain TRP channel is expressed in a subset of sensory neurons and involved in behavioral responses to thermal, chemical, and mechanical stimuli. Its physiological roles in brain neurons, however, remain largely elusive. Using multiple mutant alleles and tranformants for pain, here we demonstrate that the brain-expressed Pain TRP channel is required for long-term memory (LTM), but not for short-lasting memory, induced by courtship conditioning in adult males. The courtship LTM phenotype in pain mutants was rescued by expressing wild-type pain temporarily, prior to conditioning, in adult flies. In addition, targeted expression of painRNAi in either the mushroom bodies (MBs) or insulin-producing cells (IPCs) resulted in defective courtship LTM. These results indicate that the Pain TRP channels in the MBs and IPCs control neuronal plasticity that is required for the formation of a certain type of long-lasting associative memory in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.