ArticleNeuroImage2013
Brain development and aging: overlapping and unique patterns of change.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 159 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
159 citing papers in PubMed, 3 syntheses or guidelines pooled it, 300 citations in OpenAlex.
- A systematic review of neuroimaging epigenetic research: calling for an increased focus on development.Molecular psychiatry · 2023Pooled it
- Genetic influences on individual differences in longitudinal changes in global and subcortical brain volumes: Results of the ENIGMA plasticity working group.Human brain mapping · 2017Pooled it
- The effect of alcohol consumption on the adolescent brain: A systematic review of MRI and fMRI studies of alcohol-using youth.NeuroImage. Clinical · 2014Pooled it
- Methylphenidate Effects on Cortical Thickness in Children and Adults with Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial.AJNR. American journal of neuroradiology · 2020Trial
- Using real-time fMRI to influence effective connectivity in the developing emotion regulation network.NeuroImage · 2016Trial
- Brain structural pathways linking dietary patterns and cognitive performance in adolescents.Brain structure & function · 2026Article
- Characteristic differences in somatosensory ERP components in Go/No-go paradigm between adolescents and adults.Experimental brain research · 2026Article
- Language dysfunction as a primary feature of cognitive decline in neurological populations.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Longitudinal associations between air pollution and adolescent gray matter development: Insights from the ABCD study.Environmental research · 2026Article
- Mapping heterogeneous region- and tissue-specific brain ageing patterns using quantitative MRI.Brain communications · 2026Article
- Individual Differences in Developmental Trajectories of Global and Subcortical Brain Volumes Between Late Childhood and Late Adolescence: Findings From a 12-Wave Neuroimaging Study.Human brain mapping · 2025Article
- Age-related constraints on the spatial geometry of the brain.Nature communications · 2025Article
- Does restrictive anorexia nervosa impact brain aging? A machine learning approach to estimate age based on brain structure.Computers in biology and medicine · 2025Article
- Mapping Individual Differences in Intermodal Coupling in Neurodevelopment.bioRxiv : the preprint server for biology · 2025Article
- Microstructural Characterization of Short Association Fibers Related to Long-Range White Matter Tracts in Normative Development.Human brain mapping · 2025Article
- Longitudinal Sex-at-Birth and Age Analyses of Cortical Structure in the ABCD Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Temporoparietal brain structures support sentence processing across the adult lifespan.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Mapping individual differences in intermodal coupling in neurodevelopment.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Population clustering of structural brain aging and its association with brain development.eLife · 2024Article
- Increases in regional brain volume across two native South American male populations.GeroScience · 2024Article
99 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Early-life development is characterized by dramatic changes, impacting lifespan function more than changes in any other period. Developmental origins of neurocognitive late-life functions are acknowledged, but detailed longitudinal magnetic resonance imaging studies of brain maturation and direct comparisons with aging are lacking. To these aims, a novel method was used to measure longitudinal volume changes in development (n=85, 8-22 years) and aging (n=142, 60-91 years). Developmental reductions exceeded 1% annually in much of the cortex, more than double to that seen in aging, with a posterior-to-anterior gradient. Cortical reductions were greater than the subcortical during development, while the opposite held in aging. The pattern of lateral cortical changes was similar across development and aging, but the pronounced medial temporal reduction in aging was not precast in development. Converging patterns of change in adolescents and elderly, particularly in the medial prefrontal areas, suggest that late developed cortices are especially vulnerable to atrophy in aging. A key question in future research will be to disentangle the neurobiological underpinnings for the differences and the similarities between brain changes in development and aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.