ArticleNeuroImage2013
Association between heart rate variability and fluctuations in resting-state functional connectivity.
Article in NeuroImage, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 216 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
216 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- From Lung to Brain: Respiration Modulates Neural and Mental Activity.Neuroscience bulletin · 2023Pooled it
- History of concussion and lowered heart rate variability at rest beyond symptom recovery: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Intoxication due to Δ9-tetrahydrocannabinol is characterized by disrupted prefrontal cortex activity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Trial
- Ketamine induces multiple individually distinct whole-brain functional connectivity signatures.eLife · 2024Trial
- Effects of cortisol administration on heart rate variability and functional connectivity across women with different depression histories.Behavioural brain research · 2024Trial
- Heart rate variability (HRV) changes and cortical volume changes in a randomized trial of five weeks of daily HRV biofeedback in younger and older adults.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2022Trial
- Identification of ∆9-tetrahydrocannabinol (THC) impairment using functional brain imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Trial
- Ketamine effects on default mode network activity and vigilance: A randomized, placebo-controlled crossover simultaneous fMRI/EEG study.Human brain mapping · 2020Trial
- Trial
- Altered Insula Connectivity under MDMA.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Eating disinhibition and vagal tone moderate the postprandial response to glycemic load: a randomised controlled trial.Scientific reports · 2016Trial
- Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects.The international journal of neuropsychopharmacology · 2015Trial
- Ketamine-Induced Modulation of the Thalamo-Cortical Network in Healthy Volunteers As a Model for Schizophrenia.The international journal of neuropsychopharmacology · 2015Trial
- Cognitive effects and autonomic responses to transcranial pulsed current stimulation.Experimental brain research · 2015Trial
- Autonomic Network Signatures of Interictal Cardiorespiratory Dysfunction in Patients With Temporal Lobe Epilepsy.Neurology · 2026Article
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Article
- Distinct Brain Systems Support Afferent and Efferent Autonomic Activity.bioRxiv : the preprint server for biology · 2026Article
- System identification and surrogate data analyses imply approximate Gaussianity and non-stationarity of resting-brain dynamics.bioRxiv : the preprint server for biology · 2026Article
- Sleep deprivation exhibits an age-dependent effect on infraslow global brain activity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
156 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Functional connectivity has been observed to fluctuate across the course of a resting state scan, though the origins and functional relevance of this phenomenon remain to be shown. The present study explores the link between endogenous dynamics of functional connectivity and autonomic state in an eyes-closed resting condition. Using a sliding window analysis on resting state fMRI data from 35 young, healthy male subjects, we examined how heart rate variability (HRV) covaries with temporal changes in whole-brain functional connectivity with seed regions previously described to mediate effects of vigilance and arousal (amygdala and dorsal anterior cingulate cortex; dACC). We identified a set of regions, including brainstem, thalamus, putamen, and dorsolateral prefrontal cortex, that became more strongly coupled with the dACC and amygdala seeds during states of elevated HRV. Effects differed between high and low frequency components of HRV, suggesting specific contributions of parasympathetic and sympathetic tone on individual connections. Furthermore, dynamics of functional connectivity could be separated from those primarily related to BOLD signal fluctuations. The present results contribute novel information about the neural basis of transient changes of autonomic nervous system states, and suggest physiological and psychological components of the recently observed non-stationarity in resting state functional connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.