ArticleRespiratory physiology & neurobiology2013
Isoflurane and ketamine anesthesia have different effects on ventilatory pattern variability in rats.
Article in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 10 citations in OpenAlex.
- Effect of Sex, Anesthesia Method, Physiological Asymmetry, and Strain on Rat Lymphatic Vessel Contractility Assessed via Near-Infrared Spectroscopy and Linear Mixed-Effects Modeling.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Respiratory rate as a X-ray-based biomarker for the longitudinal assessment of lung function and pathology.Frontiers in medicine · 2025Article
- Perturbing cortical networks:Frontiers in neuroscience · 2024Article
- Commonly used anesthetics modify alcohol and (-)-trans-delta9-tetrahydrocannabinol in vivo effects on rat cerebral arterioles.BMC anesthesiology · 2023Article
- Dynamics of ventilatory pattern variability and Cardioventilatory Coupling during systemic inflammation in rats.Frontiers in network physiology · 2023Article
- Albumin-derived perfluorocarbon-based artificial oxygen carriers can avoid hypoxic tissue damage in massive hemodilution.Scientific reports · 2020Article
- Plasticity Induced Recovery of Breathing Occurs at Chronic Stages after Cervical Contusion.Journal of neurotrauma · 2019Article
- Mid-cervical spinal cord contusion causes robust deficits in respiratory parameters and pattern variability.Experimental neurology · 2018Article
- Diaphragm muscle activity across respiratory motor behaviors in awake and lightly anesthetized rats.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Different sensitivity to the suppressive effects of isoflurane anesthesia on cardiorespiratory function in SHR/Izm, WKY/Izm, and Crl:CD (SD) rats.Experimental animals · 2016Article
- Perioperative sleep apnea: a real problem or did we invent a new disease?F1000Research · 2016Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We hypothesize that isoflurane and ketamine impact ventilatory pattern variability (VPV) differently. Adult Sprague-Dawley rats were recorded in a whole-body plethysmograph before, during and after deep anesthesia. VPV was quantified from 60-s epochs using a complementary set of analytic techniques that included constructing surrogate data sets that preserved the linear structure but disrupted nonlinear deterministic properties of the original data. Even though isoflurane decreased and ketamine increased respiratory rate, VPV as quantified by the coefficient of variation decreased for both anesthetics. Further, mutual information increased and sample entropy decreased and the nonlinear complexity index (NLCI) increased during anesthesia despite qualitative differences in the shape and period of the waveform. Surprisingly mutual information and sample entropy did not change in the surrogate sets constructed from isoflurane data, but in those constructed from ketamine data, mutual information increased and sample entropy decreased significantly in the surrogate segments constructed from anesthetized relative to unanesthetized epochs. These data suggest that separate mechanisms modulate linear and nonlinear variability of breathing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.