ArticleGenome biology and evolution2013
Genome-wide scans for candidate genes involved in the aquatic adaptation of dolphins.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- The genomic basis of independent marine transitions in turtles: convergent episodic adaptation and demographic shifts.Molecular biology and evolution · 2026Article
- Evolutionary Complexity of Primate Immune System Uncovered by the Extensive Phylogenomic Sampling.Genome biology and evolution · 2026Article
- Phylogenomic Approaches to Study Adaptive Evolution in Mammals: From Aging to Aquatic Lifestyles.Annual review of genetics · 2025Review
- Evolution of ion channels in cetaceans: a natural experiment in the tree of life.Scientific reports · 2024Article
- New chromosome-scale genomes provide insights into marine adaptations of sea snakes (Hydrophis: Elapidae).BMC biology · 2023Article
- Genomic Divergence and the Evolution of Ecotypes in Bottlenose Dolphins (Genus Tursiops).Genome biology and evolution · 2023Article
- Genomics of Adaptations in Ungulates.Animals : an open access journal from MDPI · 2021Review
- Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales.Life (Basel, Switzerland) · 2021Review
- AutoSeqMan: batch assembly of contigs for Sanger sequences.Zoological research · 2018Article
- Positive and relaxed selection associated with flight evolution and loss in insect transcriptomes.GigaScience · 2017Article
- Adaptive Evolution of Energy Metabolism-Related Genes in Hypoxia-Tolerant Mammals.Frontiers in genetics · 2017Article
- Hundreds of Genes Experienced Convergent Shifts in Selective Pressure in Marine Mammals.Molecular biology and evolution · 2016Article
- Article
- Fifteen years of genomewide scans for selection: trends, lessons and unaddressed genetic sources of complication.Molecular ecology · 2016Review
- 'Obesity' is healthy for cetaceans? Evidence from pervasive positive selection in genes related to triacylglycerol metabolism.Scientific reports · 2015Article
- A phylogenomic analysis of the role and timing of molecular adaptation in the aquatic transition of cetartiodactyl mammals.Royal Society open science · 2015Article
- Transcriptome sequencing of three Ranunculus species (Ranunculaceae) reveals candidate genes in adaptation from terrestrial to aquatic habitats.Scientific reports · 2015Article
- Transcriptome analysis of northern elephant seal (Mirounga angustirostris) muscle tissue provides a novel molecular resource and physiological insights.BMC genomics · 2015Article
- Article
- Genome-wide analysis of positively selected genes in seasonal and non-seasonal breeding species.PloS one · 2015Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since their divergence from the terrestrial artiodactyls, cetaceans have fully adapted to an aquatic lifestyle, which represents one of the most dramatic transformations in mammalian evolutionary history. Numerous morphological and physiological characters of cetaceans have been acquired in response to this drastic habitat transition, such as thickened blubber, echolocation, and ability to hold their breath for a long period of time. However, knowledge about the molecular basis underlying these adaptations is still limited. The sequence of the genome of Tursiops truncates provides an opportunity for a comparative genomic analyses to examine the molecular adaptation of this species. Here, we constructed 11,838 high-quality orthologous gene alignments culled from the dolphin and four other terrestrial mammalian genomes and screened for positive selection occurring in the dolphin lineage. In total, 368 (3.1%) of the genes were identified as having undergone positive selection by the branch-site model. Functional characterization of these genes showed that they are significantly enriched in the categories of lipid transport and localization, ATPase activity, sense perception of sound, and muscle contraction, areas that are potentially related to cetacean adaptations. In contrast, we did not find a similar pattern in the cow, a closely related species. We resequenced some of the positively selected sites (PSSs), within the positively selected genes, and showed that most of our identified PSSs (50/52) could be replicated. The results from this study should have important implications for our understanding of cetacean evolution and their adaptations to the aquatic environment.
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