ArticleGenome biology and evolution2013
Natural genome diversity of AI-2 quorum sensing in Escherichia coli: conserved signal production but labile signal reception.
Article in Genome biology and evolution, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- An innovative strategy to treat pathogenic biofilm-associated infectionsRSC medicinal chemistry · 2025Article
- Autoinducer-2-mediated communication network within human gut microbiota.The ISME journal · 2025Article
- Less is more: the lack of autoinducer-2-dependent quorum sensing promotes competitive fitness ofFrontiers in cellular and infection microbiology · 2025Article
- Dual-Species Biofilms: Biomass, Viable Cell Ratio/Cross-Species Interactions, Conjugative Transfer.International journal of molecular sciences · 2023Article
- Individual bacteria in structured environments rely on phenotypic resistance to phage.PLoS biology · 2021Article
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- Invasion of Epithelial Cells Is Correlated with Secretion of Biosurfactant via the Type 3 Secretion System (T3SS) ofJournal of pathogens · 2020Article
- Exposure to Sub-inhibitory Concentrations of the Chemosensitizer 1-(1-Naphthylmethyl)-Piperazine Creates Membrane Destabilization in Multi-Drug ResistantFrontiers in microbiology · 2019Article
- Regulation of bacteria population behaviors by AI-2 "consumer cells" and "supplier cells".BMC microbiology · 2017Article
- LuxS-dependent AI-2 production is not involved in global regulation of natural product biosynthesis inPeerJ · 2017Article
- Analysis of the genomic sequences and metabolites of Serratia surfactantfaciens sp. nov. YD25BMC genomics · 2016Article
- Genes as Cues of Relatedness and Social Evolution in Heterogeneous Environments.PLoS computational biology · 2016Article
- Thiophenone Attenuates Enteropathogenic Escherichia coli O103:H2 Virulence by Interfering with AI-2 Signaling.PloS one · 2016Article
- Article
- Integration of AI-2 Based Cell-Cell Signaling with Metabolic Cues in Escherichia coli.PloS one · 2016Article
- Mutation rate plasticity in rifampicin resistance depends on Escherichia coli cell-cell interactions.Nature communications · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Quorum sensing (QS) regulates the onset of bacterial social responses in function to cell density having an important impact in virulence. Autoinducer-2 (AI-2) is a signal that has the peculiarity of mediating both intra- and interspecies bacterial QS. We analyzed the diversity of all components of AI-2 QS across 44 complete genomes of Escherichia coli and Shigella strains. We used phylogenetic tools to study its evolution and determined the phenotypes of single-deletion mutants to predict phenotypes of natural strains. Our analysis revealed many likely adaptive polymorphisms both in gene content and in nucleotide sequence. We show that all natural strains possess the signal emitter (the luxS gene), but many lack a functional signal receptor (complete lsr operon) and the ability to regulate extracellular signal concentrations. This result is in striking contrast with the canonical species-specific QS systems where one often finds orphan receptors, without a cognate synthase, but not orphan emitters. Our analysis indicates that selection actively maintains a balanced polymorphism for the presence/absence of a functional lsr operon suggesting diversifying selection on the regulation of signal accumulation and recognition. These results can be explained either by niche-specific adaptation or by selection for a coercive behavior where signal-blind emitters benefit from forcing other individuals in the population to haste in cooperative behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.