Evidence map›Paper›PMID 23246640›Full record

Trial reportThe Journal of steroid biochemistry and molecular biology2013

The effect of vitamin D supplementation on serum 25(OH)D in thin and obese women.

J Christopher Gallagher, Vinod Yalamanchili, Lynette M Smith

Abstract readRandomized Controlled TrialReview
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of steroid biochemistry and molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
83citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

83 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Effect of 12-Week BMI-Based Vitamin DInternational journal of molecular sciences · 2023
    Trial
  7. Trial
  8. Trial
  9. Sixteen-Week Vitamin DNutrients · 2022
    Trial
  10. Trial
  11. Trial
  12. Trial
  13. Evolution of Serum 25OHD in Response to Vitamin DJournal of the American College of Nutrition · 2018
    Trial
  14. Reduced-fat Gouda-type cheese enriched with vitamin DEuropean journal of nutrition · 2017
    Trial
  15. Trial
  16. Trial
  17. Three doses of vitamin D, bone mineral density, and geometry in older women during modest weight control in a 1-year randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Trial
  18. Trial
  19. Article
  20. Article

23 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

J Christopher GallagherBone Metabolism Unit, Creighton University Medical Center, Omaha, NE, United States. jcg@creighton.edu
Vinod Yalamanchili
Lynette M Smith

Funding

Determination of RDA for Vitamin D in Caucasian and African American WomenR01AG028168 · NIA · CREIGHTON UNIVERSITY · PI GALLAGHER, JOHN CHRISTOPHER · 2006 to 2009
$1.9M
NIA NIH HHS R01 AG028168
6 · The paper itself

Abstract

Obese people are known to have lower serum 25OHD levels compared to non-obese people. It is not known whether it is due to storage of vitamin D in fat, inadequate input from sunlight, diet or other unknown factors. We examined the relationship at study baseline of serum 25OHD, PTH, 1,25(OH)2D with body composition measurements using dual energy X-ray absorptiometry. The results showed a significant inverse relation between total body fat mass and serum 25OHD (p<0.0001) and serum 1,25(OH2)D (p=034) and an independent positive correlation between serum PTH and total body fat mass (p<0.0001). In a randomized controlled study of seven doses of vitamin D (400-4800IU/d) the increase in serum 25OHD levels was compared in women with a normal body mass index to obese women. The response to the low doses of vitamin D (400-800IU/d) was significantly less than that of the medium (1600-2400IU/d) and high doses groups (3200-4800IU) (p<0.0001) in all BMI categories. The increase in serum 25OHD in the medium and high dose groups was not significantly different with increasing level of obesity. But thinner women with a normal BMI (<25kg/m(2)) showed a much higher response to vitamin D at any dose level compared to other BMI groups. There was no significant change in total body fat mass after treatment with vitamin D or calcitriol in our randomized trials. In summary, the response to vitamin D is dependent on body weight. Women with BMI <25kg/m(2) develop much higher levels of serum 25OHD after vitamin D supplementation compared to those with BMI of >25kg/m(2). The differences in serum 25OHD levels between normal and obese women may be due to differences in volume dilution. After vitamin D supplementation, all obese women reach adequate levels of serum 25OHD but normal women (BMI<25kg/m(2)) reach much higher levels of 25OHD and in this group smaller doses of vitamin D used should be used. This article is part of a Special Issue entitled 'Vitamin D Workshop'.

Indexed as

AgedAged, 80 and overBody CompositionBody Mass IndexCalcitriolDietary SupplementsDouble-Blind MethodFemaleHumansLongitudinal StudiesMiddle AgedObesityVitamin D25-hydroxyvitamin DCalcitriolVitamin D

Identifiers

PMID23246640
PMCPMC3686842

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.