ArticleHeart rhythm2013
Sympathetic nerve fibers and ganglia in canine cervical vagus nerves: localization and quantitation.
Article in Heart rhythm, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Autonomic dysregulation and atrial arrhythmias.American journal of physiology. Cell physiology · 2025Review
- Tyrosine Hydroxylase-Expressing Neurons in the Vagal Ganglia: Characterization and Implications.Biomedicines · 2025Article
- Autonomic control of the pulmonary circulation: Implications for pulmonary hypertension.Experimental physiology · 2025Review
- Analgesic Effect of Auricular Vagus Nerve Stimulation on Oxaliplatin-induced Peripheral Neuropathic Pain in a Rodent Model.Experimental neurobiology · 2024Article
- The differences in the anatomy of the thoracolumbar and sacral autonomic outflow are quantitative.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Autonomic Modulation of Atrial Fibrillation.JACC. Basic to translational science · 2023Review
- Spatially selective stimulation of the pig vagus nerve to modulate target effect versus side effect.Journal of neural engineering · 2023Article
- Measuring and modeling the effects of vagus nerve stimulation on heart rate and laryngeal muscles.Bioelectronic medicine · 2023Article
- Sympathetic components in left and right human cervical vagus nerve: implications for vagus nerve stimulation.Frontiers in neuroanatomy · 2023Article
- Subcutaneous nerve stimulation reduces sympathetic nerve activity in ambulatory dogs with myocardial infarction.Heart rhythm · 2020Article
- Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation.Journal of neural engineering · 2020Article
- Subcutaneous nerve stimulation for rate control in ambulatory dogs with persistent atrial fibrillation.Heart rhythm · 2019Article
- Cardiac Afferent Denervation Abolishes Ganglionated Plexi and Sympathetic Responses to Apnea: Implications for Atrial Fibrillation.Circulation. Arrhythmia and electrophysiology · 2019Article
- Heart Rate Variability and Vagus Nerve Stimulation in Epilepsy Patients.Translational neuroscience · 2019Article
- Vagus Nerve Stimulation in Rodent Models: An Overview of Technical Considerations.Frontiers in neuroscience · 2019Review
- Effects of Vagal Nerve Stimulation on Ganglionated Plexi Nerve Activity and Ventricular Rate in Ambulatory Dogs With Persistent Atrial Fibrillation.JACC. Clinical electrophysiology · 2018Article
- Antiarrhythmic effects of vagal nerve stimulation after cardiac sympathetic denervation in the setting of chronic myocardial infarction.Heart rhythm · 2018Article
- Antiarrhythmic effects of stimulating the left dorsal branch of the thoracic nerve in a canine model of paroxysmal atrial tachyarrhythmias.Heart rhythm · 2018Article
- Left cervical vagal nerve stimulation reduces skin sympathetic nerve activity in patients with drug resistant epilepsy.Heart rhythm · 2017Article
- Modulation of experimental arthritis by vagal sensory and central brain stimulation.Brain, behavior, and immunity · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCervical vagal nerve (CVN) stimulation may improve left ventricular ejection fraction in patients with heart failure.
objectivesTo test the hypothesis that sympathetic structures are present in the CVN and to describe the location and quantitate these sympathetic components of the CVN.
methodsWe performed immunohistochemical studies of the CVN from 11 normal dogs and simultaneously recorded stellate ganglion nerve activity, left thoracic vagal nerve activity, and subcutaneous electrocardiogram in 2 additional dogs.
resultsA total of 28 individual nerve bundles were present in the CVNs of the first 11 dogs, with an average of 1.87±1.06 per dog. All CVNs contain tyrosine hydroxylase-positive (sympathetic) nerves, with a total cross-sectional area of 0.97±0.38 mm(2). The sympathetic nerves were nonmyelinated, typically located at the periphery of the nerve bundles and occupied 0.03%-2.80% of the CVN cross-sectional area. Cholineacetyltransferase-positive nerve fibers occupied 12.90%-42.86% of the CVN cross-sectional areas. Ten of 11 CVNs showed tyrosine hydroxylase and cholineacetyltransferase colocalization. In 2 dogs with nerve recordings, we documented heart rate acceleration during spontaneous vagal nerve activity in the absence of stellate ganglion nerve activity.
conclusionsSympathetic nerve fibers are invariably present in the CVNs of normal dogs and occupy in average up to 2.8% of the cross-sectional area. Because sympathetic nerve fibers are present in the periphery of the CVNs, they may be susceptible to activation by electrical stimulation. Spontaneous activation of the sympathetic component of the vagal nerve may accelerate the heart rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.