ArticleHeart rhythm2013
Pro- and antiarrhythmic effects of ATP-sensitive potassium current activation on reentry during early afterdepolarization-mediated arrhythmias.
Article in Heart rhythm, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Role of ryanodine receptor cooperativity in CaThe Journal of physiology · 2024Article
- Bistable spiral wave dynamics in electrically excitable media.Physical review. E · 2023Article
- Calcium Handling Defects and Cardiac Arrhythmia Syndromes.Frontiers in pharmacology · 2020Review
- Optimization of anFrontiers in physiology · 2017Article
- Spatial Patterns of Excitation at Tissue and Whole Organ Level Due to Early Afterdepolarizations.Frontiers in physiology · 2017Review
- Effects of early afterdepolarizations on excitation patterns in an accurate model of the human ventricles.PloS one · 2017Article
- Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome.American journal of physiology. Heart and circulatory physiology · 2016Article
- Perspective: a dynamics-based classification of ventricular arrhythmias.Journal of molecular and cellular cardiology · 2015Review
- Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence.Annual review of physiology · 2015Review
- Nonlinear and Stochastic Dynamics in the Heart.Physics reports · 2014Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundUnder conditions promoting early afterdepolarizations (EADs), ventricular tissue can become bi-excitable, that is, capable of wave propagation mediated by either the Na current (INa) or the L-type calcium current (ICa,L), raising the possibility that ICa,L-mediated reentry may contribute to polymorphic ventricular tachycardia (PVT) and torsades de pointes. ATP-sensitive K current (IKATP) activation suppresses EADs, but the effects on ICa,L-mediated reentry are unknown.
objectiveTo investigate the effects of IKATP activation on ICa,L-mediated reentry.
methodsWe performed optical voltage mapping in cultured neonatal rat ventricular myocyte monolayers exposed to BayK8644 and isoproterenol. The effects of pharmacologically activating IKATP with pinacidil were analyzed.
resultsIn 13 monolayers with anatomic ICa,L-mediated reentry around a central obstacle, pinacidil (50 μM) converted ICa,L-mediated reentry to INa-mediated reentry. In 33 monolayers with functional ICa,L-mediated reentry (spiral waves), pinacidil terminated reentry in 17, converted reentry into more complex INa-mediated reentry resembling fibrillation in 12, and had no effect in 4. In simulated 2-dimensional bi-excitable tissue in which ICa,L- and INa-mediated wave fronts coexisted, slow IKATP activation (over minutes) reliably terminated rotors but rapid IKATP activation (over seconds) often converted ICa,L-mediated reentry to INa-mediated reentry resembling fibrillation.
conclusionsIKATP activation can have proarrhythmic effects on EAD-mediated arrhythmias if ICa,L-mediated reentry is present.
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