ArticleMolecular cell2013
Integration-dependent bacteriophage immunity provides insights into the evolution of genetic switches.
Article in Molecular cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 87 citations in OpenAlex.
- Revisiting the life cycle of temperate phages.Nature reviews. Microbiology · 2026Review
- Counting to two: how phages decide between lysis and lysogeny.bioRxiv : the preprint server for biology · 2026Article
- Genetic Engineering of Lysogenic-Lytic Switch Genes ImprovesInternational journal of molecular sciences · 2026Article
- Genome synthesis, assembly, and rebooting of therapeutically useful high G+C% mycobacteriophages.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- All the world's a phage.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Mycobacteriophage Yasnaya_Polyana and its engineered lytic derivative: specificity of regulatory motifs and lytic potential.Frontiers in microbiology · 2025Article
- Genomic analysis of seven mycobacteriophages identifies three novel species with differing phenotypic stabilities.Heliyon · 2024Article
- Article
- Characterization of novel recombinant mycobacteriophages derived from homologous recombination between two temperate phages.G3 (Bethesda, Md.) · 2023Article
- Unusual prophages in Mycobacterium abscessus genomes and strain variations in phage susceptibilities.PloS one · 2023Article
- Mycobacteriophage Tarkin: a Cluster E Phage.Microbiology resource announcements · 2022Article
- Phylogenomic analyses and host range prediction of cluster P mycobacteriophages.G3 (Bethesda, Md.) · 2022Article
- Mycobacteriophages: From Petri dish to patient.PLoS pathogens · 2022Review
- Alternating lysis and lysogeny is a winning strategy in bacteriophages due to Parrondo's paradox.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genomic Characterisation of UFJF_PfDIW6: A Novel LyticViruses · 2022Article
- AimR Adopts Preexisting Dimer Conformations for Specific Target Recognition in Lysis-Lysogeny Decisions ofBiomolecules · 2021Article
- AreViruses · 2021Article
- Increased whiB7 expression and antibiotic resistance in Mycobacterium chelonae carrying two prophages.BMC microbiology · 2021Article
- Article
- Engineered Bacteriophage Therapeutics: Rationale, Challenges and Future.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2021Review
2 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Genetic switches are critical components of developmental circuits. Because temperate bacteriophages are vastly abundant and greatly diverse, they are rich resources for understanding the mechanisms and evolution of switches and the molecular control of genetic circuitry. Here, we describe a new class of small, compact, and simple switches that use site-specific recombination as the key decision point. The phage attachment site attP is located within the phage repressor gene such that chromosomal integration results in removal of a C-terminal tag that destabilizes the virally encoded form of the repressor. Integration thus not only confers prophage stability but also is a requirement for lysogenic establishment. The variety of these self-contained integration-dependent immunity systems in different genomic contexts suggests that these represent ancestral states in switch evolution from which more-complex switches have evolved. They also provide a powerful toolkit for building synthetic biological circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.