ArticleAmerican journal of human genetics2013
Refinement in localization and identification of gene regions associated with Crohn disease.
Article in American journal of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Interferon Regulator Factor 5: A Novel Inflammatory Marker and Promising Therapeutic Target in Ulcerative Colitis.Biomedicines · 2025Article
- Unravelling the Oral-Gut Axis: Interconnection Between Periodontitis and Inflammatory Bowel Disease, Current Challenges, and Future Perspective.Journal of Crohn's & colitis · 2024Review
- Linkage disequilibrium maps for European and African populations constructed from whole genome sequence data.Scientific data · 2019Article
- Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.Cell reports · 2018Article
- High-Resolution Genetic Maps Identify Multiple Type 2 Diabetes Loci at Regulatory Hotspots in African Americans and Europeans.American journal of human genetics · 2017Article
- ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation.Cell death & disease · 2017Article
- Whole genome sequences are required to fully resolve the linkage disequilibrium structure of human populations.BMC genomics · 2015Article
- Phenolyzer: phenotype-based prioritization of candidate genes for human diseases.Nature methods · 2015Article
- ABCC5 transporter is a novel type 2 diabetes susceptibility gene in European and African American populations.Annals of human genetics · 2014Article
- The link between ankylosing spondylitis, Crohn's disease, Klebsiella, and starch consumption.Clinical & developmental immunology · 2013Review
- The role of Klebsiella in Crohn's disease with a potential for the use of antimicrobial measures.International journal of rheumatology · 2013Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The risk of Crohn disease (CD) has a large genetic component. A recent meta-analysis of 6 genome-wide association studies reported 71 chromosomal intervals but does not account for all of the known genetic contribution. Here, we refine localization of the previously reported intervals and also identify additional CD susceptibility genes using a mapping approach that localizes causal variants based on genetic maps in linkage disequilibrium units (LDU maps). Using 2 of the 6 cohorts, 66 of the 71 previously reported loci are confirmed and more precise location estimates for these intervals are given. We identify 78 additional gene regions that pass genome-wide significance, providing strong evidence for 144 genes. Additionally, 56 nominally significant signals, but with more stringent and precise colocalization, are identified. In total, we provide evidence for 200 gene regions confirming that CD is truly multifactorial and complex in nature. Many identified genes have functions that are compatible with involvement in immune/inflammatory processes and seem to have a large effect in individuals with extra ileal as well as ileal inflammation. The precise locations and the evidence that some genes reflect phenotypic subgroups will help identify functional variants and will lead to greater insight of CD etiology.
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