ReviewSurvey of ophthalmology
Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature.
Review in Survey of ophthalmology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 86 citations in OpenAlex.
- Spontaneous regression of a presumed orbitocranial eosinophilic granuloma in an adult patient: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Orbital Langerhans Cell Histiocytosis in Young Pediatric Patients: Two Case Reports and Literature Review.Pediatric health, medicine and therapeutics · 2026Article
- Langerhans cell histiocytosis present in a 1-day-old girl: a case report.Journal of medical case reports · 2025Article
- Review
- Langerhans cell histiocytosis presenting as a blueberry muffin rash.Dermatology reports · 2024Article
- [Differential diagnoses of benign eyelid tumors in children and adolescents].Die Ophthalmologie · 2023Review
- Successful treatment of orbital Langerhans cell histiocytosis with stereotactic radiosurgery: A case report and literature review.Clinical case reports · 2023Article
- Ophthalmic histiocytic lesions: a baseline demographic and clinicopathological study of 28 cases from two eye centers.International ophthalmology · 2022Article
- Recurrence of a Langerhans Cell Histiocytosis bone lesion in a different site: A case report.Annals of medicine and surgery (2012) · 2022Article
- Article
- Multifocal Langerhans cell histiocytosis in a child.Radiology case reports · 2021Article
- Rare Diseases of the Nose, the Paranasal Sinuses, and the Anterior Skull Base.Laryngo- rhino- otologie · 2021Review
- Locally aggressive orbital giant cell reparative granuloma in an infant: case report and literature review.International journal of clinical and experimental pathology · 2021Article
- Clinical spectrum and management outcomes of Langerhans cell histiocytosis of the orbit.Indian journal of ophthalmology · 2020Article
- Local delivery of corticosteroids in clinical ophthalmology: A review.Clinical & experimental ophthalmology · 2020Review
- MR imaging features of orbital Langerhans cell Histiocytosis.BMC ophthalmology · 2019Article
- Langerhans cell histiocytosis of a metatarsal bone in an adult female.BMJ case reports · 2019Article
- Steroid Induced Cataract in Langerhans Cell Histiocytosis Patient.Open access Macedonian journal of medical sciences · 2019Article
- Langerhans cell histiocytosis of the orbit and frontal sinus of the adult woman: A first case report in Poland.Surgical neurology international · 2019Article
- Atypical presentation of isolated orbital Langerhans cell histiocytosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2019Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells intermixed with inflammatory cells, in particular eosinophils, that may manifest as unisystem (unifocal or multifocal) or multisystem disease. Orbital involvement typically manifests as a solitary lesion that carries a favorable prognosis. We describe the clinical and histologic spectrum of LCH of the orbit in our five cases. One patient exhibited multifocal unisystem disease; the other four had a localized process. Typical histologic features included numerous histiocytes with varying degrees of giant cell formation and scattered eosinophilic granulocytes. The presence of Langerhans cells was confirmed by CD1a and S100 immunohistochemistry. Transmission electron microscopy demonstrated characteristic intracytoplasmic Birbeck granules. We review the different ophthalmic manifestations of LCH and treatment strategies. As LCH may solely involve the orbit, treatment is based on the degree of organ involvement. LCH should included in the differential diagnosis in tumors of the ocular adnexae, especially in young children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.