Trial reportAmerican journal of ophthalmology2013
Risk of endophthalmitis and other long-term complications of trabeculectomy in the Collaborative Initial Glaucoma Treatment Study (CIGTS).
Trial report in American journal of ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Aqueous shunts for glaucoma.The Cochrane database of systematic reviews · 2017Pooled it
- Comparing the efficacy of trabeculectomy and diode laser cyclophotocoagulation in primary open-angle glaucoma.International ophthalmology · 2019Trial
- Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2019Trial
- Endophthalmitis following glaucoma drainage device surgery.Eye (London, England) · 2026Article
- Management and outcomes of primary open-angle glaucoma.Journal of family medicine and primary care · 2026Review
- A-stream glaucoma shunt versus trabeculectomy: 1-year results on efficacy and safety.Scientific reports · 2026Article
- STING deficiency alleviates scar formation after glaucoma filtration surgery by suppressing p38 MAPK-induced inflammation in mice.Eye and vision (London, England) · 2026Article
- Efficacy and safety evaluation of phacoemulsification with intraocular lens implantation combined with goniotomy versus combined with trabeculectomy in advanced pseudoexfoliative glaucoma with cataract.BMC ophthalmology · 2025Article
- Blebitis after temporal approach MSICS and phacoemulsification performed post-trabeculectomy: incidence, management, and outcomes at ECWA eye hospital, Kano.International ophthalmology · 2025Article
- Optimizing the sequential approach of combined phacoemulsification and gonioscopy-assisted transluminal trabeculotomy (GATT) in primary open-angle glaucoma.BMC ophthalmology · 2025Article
- Treating Glaucoma in Intellectually Disabled Patients: Novel Criteria for Choosing Surgical Candidates.Journal of ophthalmology · 2025Article
- Trends in Glaucoma Fellowship Surgical Experience.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Evaluating the 1-year success and safety of ab interno canaloplasty in combination with cataract surgery in glaucoma patients.International ophthalmology · 2024Article
- Is the Advent of New Surgical Procedures Changing the Baseline Features of Patients Undergoing First-Time Glaucoma Surgery?Journal of clinical medicine · 2024Article
- Five-year outcomes of ab interno Xen 45 gel stent implantation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- PRESERFLO MicroShunt implantation versus trabeculectomy for primary open-angle glaucoma: a two-year follow-up study.Eye and vision (London, England) · 2023Article
- [Is mitomycin C always necessary as an adjuvant to trabeculectomy?]Die Ophthalmologie · 2023Article
- [The use of antimetabolites in filtrating glaucoma surgery (trabeculectomy, XEN, Preserflo)].Die Ophthalmologie · 2023Article
- Disparities in Glaucoma Surgery: A Review of Current Evidence and Future Directions for Improvement.Translational vision science & technology · 2023Review
- The effectiveness and safety of one-stage iStent-based micro-invasive glaucoma surgery-A retrospective study.Frontiers in medicine · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo report the risk of endophthalmitis and other long-term complications in patients randomized to trabeculectomy in the Collaborative Initial Glaucoma Treatment Study.
designA longitudinal cohort study using data collected from a multicenter, randomized clinical trial.
methodsLong-term postoperative complications in the 300 patients randomized to trabeculectomy in the Collaborative Initial Glaucoma Treatment Study were tabulated. Kaplan-Meier analyses were used to estimate the time-related probabilities of blebitis, hypotony, and endophthalmitis.
resultsTwo hundred eighty-five patients were included in the final trabeculectomy cohort after accounting for declining treatment assignment and other early events. Patients were followed up for an average of 7.2 years. One hundred sixty-three patients (57%) received 5-fluorouracil during surgery. Of the 247 patients with at least 5 years of follow-up, 50 required further treatment for glaucoma. Cataract extraction was performed in 57 patients (20%). Forty patients (14%) required bleb revision at least once. Bleb-related complications included bleb leak (n = 15), blebitis (n = 8), and hypotony (n = 4). Three patients were noted to have endophthalmitis, although the diagnosis in 2 patients was presumptive. The occurrences of blebitis, hypotony, or endophthalmitis were not significantly associated with 5-fluorouracil use. The Kaplan-Meier calculated risks of blebitis and hypotony at 5 years were both 1.5%, whereas the risk of endophthalmitis was 1.1%.
conclusionsThe potential efficacy of trabeculectomy must be weighed against the long-term risk of complications, especially endophthalmitis, when selecting treatments for patients with open-angle glaucoma. We report a low 5-year risk of endophthalmitis (1.1%) and other bleb-related complications in the trabeculectomy cohort of the Collaborative Initial Glaucoma Treatment Study.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.