Evidence map›Paper›PMID 23245768›Full record

ArticleTrends in endocrinology and metabolism: TEM2013

Prolyl carboxypeptidase and its inhibitors in metabolism.

Jin Kwon Jeong, Sabrina Diano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in endocrinology and metabolism: TEM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.1field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 26 citations in OpenAlex.

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  12. POMC Neurons: From Birth to Death.Annual review of physiology · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jin Kwon JeongProgram in Integrative Cell Signaling and Neurobiology of Metabolism, Yale University School of Medicine, New Haven, CT 06520, USA.
Sabrina Diano
Yale University · US

Funding

A Carboxypeptidase in the Regulation of Hypothalamic CircuitryR01DK084065 · NIDDK · YALE UNIVERSITY · PI DIANO, SABRINA · 2010 to 2013
$1.4M
NIDDK NIH HHS DK 084065NIDDK NIH HHS R01 DK084065
6 · The paper itself

Abstract

Proopiomelanocortin (POMC)-expressing neurons in the hypothalamus integrate a variety of central and peripheral metabolic inputs, and regulate energy homeostasis by controlling energy expenditure and food intake. To accomplish this, a precise balance of production and degradation of α-melanocyte-stimulating hormone (α-MSH), an anorexigenic neuropeptide and product of the POMC gene, in the hypothalamus, is crucial. Prolyl carboxypeptidase (PRCP) is a key enzyme that degrades α-MSH to an inactive form unable to inhibit food intake. Because it represents a new therapeutic target for the treatment of metabolic disorders, such as obesity and diabetes, efforts have been made to generate potent, brain-penetrant PRCP inhibitors. Here, we discuss the role of PRCP on energy metabolism and the development of PRCP inhibitors.

Indexed as

AminopeptidasesEatingEnzyme InhibitorsHumansHypothalamusPro-OpiomelanocortinAminopeptidasesEnzyme Inhibitorsprolyl aminopeptidasePro-Opiomelanocortin

Identifiers

PMID23245768
PMCPMC3893043
OpenAlexW1964506263

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.