Trial reportBiological psychiatry2013
Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people.
Trial report in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Endogenous mu-opioid modulation of social connection in humans: a systematic review and meta-analysis.Translational psychiatry · 2024Pooled it
- A systematic and methodological review of attentional biases in eating disorders: Food, body, and perfectionism.Brain and behavior · 2019Pooled it
- What Is the Evidence for "Food Addiction?" A Systematic Review.Nutrients · 2018Pooled it
- Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Trial
- Opposing neural effects of naltrexone on food reward and aversion: implications for the treatment of obesity.Psychopharmacology · 2014Trial
- The effects of alcohol on the pharmacokinetics and pharmacodynamics of the selective mu-opioid receptor antagonist GSK1521498 in healthy subjects.Journal of clinical pharmacology · 2013Trial
- The Endogenous Opioid System in Compulsive Eating.Brain sciences · 2026Review
- Translational Perspectives on Binge-Eating: Insights from Animal Models.Current psychiatry reports · 2026Review
- Total-body imaging of mu-opioid receptors with [European journal of nuclear medicine and molecular imaging · 2024Article
- Endogenous opioids facilitate stress-induced binge eating via an insular cortex-claustrum pathway.bioRxiv : the preprint server for biology · 2024Article
- Potential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions.Nutrients · 2023Review
- Preoperative brain μ-opioid receptor availability predicts weight development following bariatric surgery in women.JCI insight · 2021Article
- Mesolimbic opioid-dopamine interaction is disrupted in obesity but recovered by weight loss following bariatric surgery.Translational psychiatry · 2021Article
- Lessons learned from using fMRI in the early clinical development of a mu-opioid receptor antagonist for disorders of compulsive consumption.Psychopharmacology · 2021Review
- Could the link between drug addiction in adulthood and substance use in adolescence result from a blurring of the boundaries between incentive and hedonic processes?Substance abuse and rehabilitation · 2019Review
- Aerobic exercise modulates anticipatory reward processing via the μ-opioid receptor system.Human brain mapping · 2018Article
- Modulation of appetitive motivation by prefrontal cortical mu-opioid receptors is dependent upon local dopamine D1 receptor signaling.Neuropharmacology · 2018Article
- μ-opioid receptor system mediates reward processing in humans.Nature communications · 2018Article
- Review
- Feeding Releases Endogenous Opioids in Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBinge eating is associated with obesity and has been conceptualized as "food addiction." However, this view has received only inconsistent support in humans, and limited evidence relates key neurocircuitry to the disorder. Moreover, relatively few studies have used pharmacologic functional magnetic resonance imaging to probe the underlying basis of altered eating behaviors.
methodsIn a double-blind, placebo-controlled, parallel group study, we explored the effects of a potent mu-opioid receptor antagonist, GSK1521498, in obese individuals with moderate binge eating. Subjects were tested during a baseline placebo run-in period and retested after 28-days of drug (n = 21) or placebo (n = 21) treatment. Using functional magnetic resonance imaging and behavioral measures, we determined the drug's effects on brain responses to food images and, separately, on motivation to expend energy to view comparable images.
resultsCompared with placebo, GSK1521498 was associated with a significant reduction in pallidum/putamen responses to pictures of high-calorie food and a reduction in motivation to view images of high-calorie food. Intriguingly, although motivational responding was reduced, subjective liking for the same images actually increased following drug treatment.
conclusionsStimulus-specific putamen/pallidal responses in obese people with binge eating are sensitive to altered mu-opioid function. This neuromodulation was accompanied by reductions in motivational responding, as measured by grip force, although subjective liking responses to the same stimuli actually increased. As well as providing evidence for a link between the opioid system and food-related behavior in binge-eating obese individuals, these results support a dissociation across measures of motivation and liking associated with food-related stimuli in these individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.