ArticleThe Journal of organic chemistry2013
Molecular library synthesis using complex substrates: expanding the framework of triterpenoids.
Article in The Journal of organic chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Bioinspired Synthesis of Twin abeo-Steroids Bufogargarizins A and B via a Divergent Intramolecular Aldol Addition Reaction.Angewandte Chemie (International ed. in English) · 2026Article
- Enhanced Cytotoxicity and Antimelanoma Activity of Novel Semisynthetic Derivatives of Betulinic Acid with Indole Conjugation.Plants (Basel, Switzerland) · 2023Article
- Late Stage Azidation of Complex Molecules.ACS central science · 2016Article
- Use of a biosynthetic intermediate to explore the chemical diversity of pseudo-natural fungal polyketides.Nature chemistry · 2015Article
- Remodeling of fumagillol: discovery of an oxygen-directed oxidative Mannich reaction.Organic letters · 2014Article
- Direct access to 6/5/7/5- and 6/7/5/5-fused tetracyclic triterpenoids via divergent transannular aldol reaction of lanosterol-derived diketone.The Journal of organic chemistry · 2013Article
- Approach for expanding triterpenoid complexity via divergent Norrish-Yang photocyclization.The Journal of organic chemistry · 2013Article
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Authors and funding
3 authors.
Funding
Abstract
The remodeling of a natural product core framework by means of diversity-oriented synthesis (DOS) is a valuable approach to access diverse/biologically relevant chemical space and to overcome the limitations of combinatorial-type compounds. Here we provide proof of principle and a thorough conformational analysis for a general strategy whereby the inherent complexity of a starting material is used to define the regio- and stereochemical outcomes of reactions in chemical library construction. This is in contrast to the traditional DOS logic employing reaction development and catalysis to drive library diversity.
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Registered trials
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