Trial reportAIDS care2013
A reanalysis of a behavioral intervention to prevent incident HIV infections: including indirect effects in modeling outcomes of Project EXPLORE.
Trial report in AIDS care, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 11 citations in OpenAlex.
- Quantitative Methods Used to Evaluate Impact of Combination HIV Prevention Intervention: A Methodological Systematic Review.AIDS and behavior · 2023Pooled it
- Guideline
- Using Novel Approaches to Evaluate Behavioral Interventions: Overlooked Significant HIV Prevention Effects in the HPTN 015 Project EXPLORE.Journal of acquired immune deficiency syndromes (1999) · 2021Trial
- Social Distancing to Mitigate COVID-19 Risks Is Associated With COVID-19 Discriminatory Attitudes Among People Living with HIV.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2020Article
- Social and behavioral health responses to COVID-19: lessons learned from four decades of an HIV pandemic.Journal of behavioral medicine · 2020Article
- Alcohol Use and Human Immunodeficiency Virus (HIV) Infection: Current Knowledge, Implications, and Future Directions.Alcoholism, clinical and experimental research · 2016Review
- Brief Report: Rethinking Data Collection for HIV Prevention Trials.Journal of acquired immune deficiency syndromes (1999) · 2016Review
- Setting the bar high or setting up to fail? Interpretations and implications of the EXPLORE Study (HPTN 015).AIDS and behavior · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Project EXPLORE - a large-scale, behavioral intervention tested among men who have sex with men (MSM) at-risk for HIV infection - was generally deemed as ineffective in reducing HIV incidence. Using novel and more precise data analytic techniques we reanalyzed Project EXPLORE by including both direct and indirect paths of intervention effects. Data from 4296 HIV-negative MSM who participated in Project EXPLORE, which included 10 sessions of behavioral risk reduction counseling completed from 1999 to 2005, were included in the analysis. We reanalyzed the data to include parameters that estimate the over-time effects of the intervention on unprotected anal (UA) sex and the over-time effects of the intervention on HIV status mediated by UA sex simultaneously in a single model. We found the indirect effect of intervention on HIV infection through UA sex to be statistically significant up through 12-month post-intervention, OR = 0.83, 95% CI = 0.72-0.95. Furthermore, the intervention significantly reduced UA sex up through 18-month post-intervention, OR = 0.79, 95% CI = 0.63-0.99. Our results reveal effects not tested in the original model that offer new insight into the effectiveness of a behavioral intervention for reducing HIV incidence. Project EXPLORE demonstrated that when tested against an evidence-based, effective control condition can result in reductions in rates of HIV acquisition at one year follow-up. Findings highlight the critical role of addressing behavioral risk reduction counseling in HIV prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.