ArticleRadiation oncology (London, England)2012
High-dose pre-operative helical tomotherapy (54 Gy) for retroperitoneal liposarcoma.
Article in Radiation oncology (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- A systematic review of margin status in retroperitoneal liposarcomas: Does the R0 margin matter?Frontiers in oncology · 2022Pooled it
- Adjuvant therapy for retroperitoneal sarcoma: a meta-analysis.Radiation oncology (London, England) · 2021Pooled it
- Intensity modulated radiation therapy and surgery for Management of Retroperitoneal Sarcomas: a single-institution experience.Radiation oncology (London, England) · 2017Trial
- Trial
- Preoperative Radiation Therapy is Not Associated with Postoperative Complications in Patients with Retroperitoneal Sarcoma.Annals of surgical oncology · 2025Article
- Potential benefits of neoadjuvant radiotherapy prior to "en bloc" compartmental resection of pure retroperitoneal liposarcomas.World journal of urology · 2024Article
- Effect of pre-operative radiation therapy on surgical outcome in retroperitoneal sarcoma.Frontiers in surgery · 2023Article
- Review
- A solitary fibrous tumour mimicking an aggressive angiomyxoma/liposarcoma.BMJ case reports · 2017Article
- Clinical outcomes of tissue expanders on adjuvant radiotherapy of resected retroperitoneal sarcoma.Medicine · 2016Article
- Long-term Oncologic Outcomes After Neoadjuvant Radiation Therapy for Retroperitoneal Sarcomas.Annals of surgery · 2015Article
- The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of retroperitoneal sarcomas.Surgical oncology · 2014Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the feasibility of pre-operative radiotherapy (54 Gy) with Helical Tomotherapy (HT) followed by surgery. METHODS AND MATERIALS: Ten patients with non-metastatic resectable retroperitoneal liposarcomas were treated by pre-operative tomotherapy (54 Gy) and surgery. Clinical and biological toxicities were evaluated on the CTCAEV3.0 scale. For nine patients, delivered tomotherapy plans were compared with retrospectively-planned dynamic intensity-modulated radiotherapy (IMRT) dosimetric studies.
resultsNo immediate or late Grade>2 toxicities were observed after radiotherapy. Post-operatively, one patient died and three patients experienced Grade 3 toxicity (two digestive and one metabolic). These toxicities disappeared and only two patients presented persistent Grade 1 paresthesia. R0 resection was obtained for four patients, R1 for four, and R2 resection for two. With a median follow-up of 26 months, no local or metastatic relapse was observed. Dosimetric comparisons between HT and retrospectively-planned IMRT demonstrate adequate target volume coverage for both techniques. Gastrointestinal sparing is higher with HT with a D200cc reduced by 5 Gy. Integral dose (ID) was increased in HT.
conclusionsHigh dose pre-operative radiotherapy (54 Gy) for retroperitoneal liposarcoma is feasible and mostly well tolerated. Cumulative toxicity and tolerance depend mainly on patient's general status. Image-guided radiation therapy (IGRT) is essential, irrespective of the IMRT technique used. Furthermore, HT offers the possibility of sparing selected areas in such complex volumes.
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