ArticleHuman genomics2012
Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations.
Article in Human genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Association of Serotonin Transporter (SERT) Polymorphisms with Opioid Dependence and Dimensional Aspects of Cocaine Use in a Caucasian Cohort of Opioid Users.Neuropsychiatric disease and treatment · 2021Article
- Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Projected Prevalence of Actionable Pharmacogenetic Variants and Level A Drugs Prescribed Among US Veterans Health Administration Pharmacy Users.JAMA network open · 2019Observational
- Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin.Pharmacogenomics · 2018Article
- The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment.Pharmacogenomics · 2017Article
- Amygdala responses to salient social cues vary with oxytocin receptor genotype in youth.Neuropsychologia · 2015Article
- Mitochondrial DNA Haplogroups and Neurocognitive Impairment During HIV Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Observational
- Epidemiology, biology, and treatment of triple-negative breast cancer in women of African ancestry.The Lancet. Oncology · 2014Review
- Characterization of mitochondrial haplogroups in a large population-based sample from the United States.Human genetics · 2014Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
This study was designed to determine the ancestral composition of a multi-ethnic sample collected for studies of drug addictions in New York City and Las Vegas, and to examine the reliability of self-identified ethnicity and three-generation family history data. Ancestry biographical scores for seven clusters corresponding to world major geographical regions were obtained using STRUCTURE, based on genotypes of 168 ancestry informative markers (AIMs), for a sample of 1,291 African Americans (AA), European Americans (EA), and Hispanic Americans (HA) along with data from 1,051 HGDP-CEPH 'diversity panel' as a reference. Self-identified ethnicity and family history data, obtained in an interview, were accurate in identifying the individual major ancestry in the AA and the EA samples (approximately 99% and 95%, respectively) but were not useful for the HA sample and could not predict the extent of admixture in any group. The mean proportions of the combined clusters corresponding to European and Middle Eastern populations in the AA sample, revealed by AIMs analysis, were 0.13. The HA subjects, predominantly Puerto Ricans, showed a highly variable hybrid contribution pattern of clusters corresponding to Europe (0.27), Middle East (0.27), Africa (0.20), and Central Asia (0.14). The effect of admixture on allele frequencies is demonstrated for two single-nucleotide polymorphisms (118A > G, 17 C > T) of the mu opioid receptor gene (OPRM1). This study reiterates the importance of AIMs in defining ancestry, especially in admixed populations.
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