ArticleBMC biology2012
Lens regeneration in axolotl: new evidence of developmental plasticity.
Article in BMC biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
41 citing papers in PubMed, 87 citations in OpenAlex.
- Exploring Larval Axolotl Brain Development: Insights Into Developmental and Functional Constraints.Evolution & development · 2026Article
- Contributions of aquatic organisms to understanding the vertebrate ocular lens.Frontiers in ophthalmology · 2026Review
- Article
- A Conserved Mechanism in Eye Optical Development: Lens Nucleus Centralization inbioRxiv : the preprint server for biology · 2025Article
- A genetically tractable non-vertebrate system to study complete camera-type eye regeneration.Nature communications · 2025Article
- Rewinding the clock: mechanisms of dedifferentiation.Current opinion in genetics & development · 2025Review
- Investigating Neotenic and Metamorphic Axolotl Brain Complexity: A Stereological and Immunohistochemical Perspective.The Journal of comparative neurology · 2025Article
- Revealing the biological features of the axolotl pancreas as a new research model.Frontiers in cell and developmental biology · 2025Article
- Ophthalmic findings and parameters in Western tiger salamanders (Ambystoma mavortium) from northern Colorado.Veterinary ophthalmology · 2025Article
- Hallmarks of regeneration.Cell stem cell · 2024Review
- Key Proteins for Regeneration inScientifica · 2024Article
- Two is not necessarily better than one: A double lens in a pre-metamorphic adult axolotl (Ambystoma mexicanum).Veterinary ophthalmology · 2023Article
- Developmental switch from morphological replication to compensatory growth for salamander lung regeneration.Cell proliferation · 2023Article
- Salamanders as Key Models for Development and Regeneration Research.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Review
- The Diverse Manifestations of Regeneration and Why We Need to Study Them.Cold Spring Harbor perspectives in biology · 2021Article
- Review
- In Vivo Imaging of Newt Lens Regeneration: Novel Insights Into the Regeneration Process.Translational vision science & technology · 2021Article
- The rax homeobox gene is mutated in the eyeless axolotl, Ambystoma mexicanum.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Salamanders: The molecular basis of tissue regeneration and its relevance to human disease.Current topics in developmental biology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundAmong vertebrates lens regeneration is most pronounced in newts, which have the ability to regenerate the entire lens throughout their lives. Regeneration occurs from the dorsal iris by transdifferentiation of the pigment epithelial cells. Interestingly, the ventral iris never contributes to regeneration. Frogs have limited lens regeneration capacity elicited from the cornea during pre-metamorphic stages. The axolotl is another salamander which, like the newt, regenerates its limbs or its tail with the spinal cord, but up until now all reports have shown that it does not regenerate the lens.
resultsHere we present a detailed analysis during different stages of axolotl development, and we show that despite previous beliefs the axolotl does regenerate the lens, however, only during a limited time after hatching. We have found that starting at stage 44 (forelimb bud stage) lens regeneration is possible for nearly two weeks. Regeneration occurs from the iris but, in contrast to the newt, regeneration can be elicited from either the dorsal or the ventral iris and, occasionally, even from both in the same eye. Similar studies in the zebra fish concluded that lens regeneration is not possible.
conclusionsRegeneration of the lens is possible in the axolotl, but differs from both frogs and newts. Thus the axolotl iris provides a novel and more plastic strategy for lens regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.