ArticleCurrent obesity reports2012
Central Leptin Regulation of Obesity and Fertility.
Article in Current obesity reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Leptin and G-protein coupled receptor (GPCR) signaling: Therapeutic potential in obesity.The Journal of biological chemistry · 2025Review
- Effects of exercise alone or combined with dietary restriction on leptin and adiponectin in overweight or obese individuals: a network meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- Unraveling the impact of hyperleptinemia on female reproduction: insights from transgenic pig model.Biological research · 2024Article
- Impact of Resistance and Endurance Training on Ghrelin and Plasma Leptin Levels in Overweight and Obese Subjects.International journal of molecular sciences · 2024Review
- The challenges of obesity for fertility: A FIGO literature review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023 · on this mapReview
- Repetitive transcranial direct current stimulation modulates the brain-gut-microbiome axis in obese rodents.Pharmacological reports : PR · 2022Article
- Maternal obesity and ovarian failure: is leptin the culprit?Animal reproduction · 2022Article
- Evening Primrose Oil Ameliorates Hyperleptinemia and Reproductive Hormone Disturbances in Obese Female Rats: Impact on Estrus Cyclicity.Frontiers in endocrinology · 2019Article
- The Complex Interactions Between Obesity, Metabolism and the Brain.Frontiers in neuroscience · 2019Review
- The Changes of Serum Leptin and Kisspeptin Levels in Chinese Children and Adolescents in Different Pubertal Stages.International journal of endocrinology · 2016Article
- Impact of obesity on infertility in women.Journal of the Turkish German Gynecological Association · 2015 · on this mapReview
- Role of dysregulated expression of leptin and leptin receptors in colorectal carcinogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Review
- Exogenous leptin administered intramuscularly induces sex hormone disorder and Ca loss via downregulation of Gnrh and PI3K expression.Experimental animals · 2014Article
- NHLH2: at the intersection of obesity and fertility.Trends in endocrinology and metabolism: TEM · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The current obesity epidemic and lack of efficient therapeutics demand a clear understanding of the mechanism underlying body weight regulation. The cloning of leptin, a key body weight regulating adipokine released in proportion to the adipose tissue mass, has revolutionized our understanding of the mechanism by which the body weight is controlled. It is now well established that the brain, especially the hypothalamus, maintains body weight homeostasis by effectively adjusting food intake and energy expenditure in response to changes in levels of various nutritional status indicators, including leptin. In addition, one major defect in physiology associated with obesity is reduced fertility. Defects in leptin action result in both obesity and infertility, suggesting that leptin may serve as a link between nutrition supply and reproduction. This review reports recent research advance in neural pathways underlying leptin action on body weight and fertility, and discusses the remaining outstanding challenges.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.