Evidence map›Paper›PMID 23243480›Full record

ArticleCurrent fungal infection reports2012

Cryptococcus gattii, no longer an accidental pathogen?

Deborah J Springer, Sujal Phadke, Blake Billmyre, Joseph Heitman

Abstract read
In one paragraph

Article in Current fungal infection reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Current Approaches in Genome Assembly of Human Fungal Pathogens.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Genotyping Analysis ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  4. A Possible Link between the Environment andInternational journal of environmental research and public health · 2022
    Article
  5. Methods for ManipulatingJournal of fungi (Basel, Switzerland) · 2021
    Review
  6. Review
  7. Isolation ofMedical mycology case reports · 2019
    Article
  8. mBio · 2019
    Article
  9. Article
  10. Article
  11. Genotypic and Phenotypic Diversity ofFrontiers in microbiology · 2018
    Article
  12. Article
  13. Fungi that Infect Humans.Microbiology spectrum · 2017
    Review
  14. Modulation of Zinc Homeostasis inFrontiers in microbiology · 2017
    Article
  15. Article
  16. Article
  17. The spectrum of fungi that infects humans.Cold Spring Harbor perspectives in medicine · 2014
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Deborah J SpringerDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.
Sujal Phadke
Blake Billmyre
Joseph Heitman

Funding

Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R37 AI039115
6 · The paper itself

Abstract

Cryptococcus gattii is an environmentally occurring pathogen that is responsible for causing cryptococcosis marked by pneumonia and meningoencephalitis in humans and animals. C. gattii can form long-term associations with trees and soil resulting in the production of infectious propagules (spores and desiccated yeast). The ever expanding reports of clinical and environmental isolation of C. gattii in temperate climates strongly imply C. gattii occurs world-wide. The key ability of yeast and spores to enter, survive, multiply, and exit host cells and to infect immunocompetent hosts distinguishes C. gattii as a primary pathogen and suggest evolution of C. gattii pathogenesis as a result of interaction with plants and other organisms in its environmental niche. Here we summarize the historical literature on C. gattii and recent literature supporting the world-wide occurrence of the primary pathogen C. gattii.

Identifiers

PMID23243480
PMCPMC3521508

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.