ArticleEvidence-based complementary and alternative medicine : eCAM2012
Green Tea Attenuates Oxidative Stress and Downregulates the Expression of Angiotensin II AT(1) Receptor in Renal and Hepatic Tissues of Streptozotocin-Induced Diabetic Rats.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Tea Consumption and Diabetes: A Comprehensive Pharmacological Review of Black, White, Green, Oolong, and Pu-erh Teas.Plants (Basel, Switzerland) · 2025Review
- Plants Used as Antihypertensive.Natural products and bioprospecting · 2021Review
- Effects and Mechanisms of Tea for the Prevention and Management of Diabetes Mellitus and Diabetic Complications: An Updated Review.Antioxidants (Basel, Switzerland) · 2019Review
- Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes.BMC complementary and alternative medicine · 2015Article
- Anti-hypertensive Herbs and their Mechanisms of Action: Part I.Frontiers in pharmacology · 2015Review
- Unexpected combined effects of NADH dehydrogenase subunit-2 237 Leu/Met polymorphism and green tea consumption on renal function in male Japanese health check-up examinees: a cross-sectional study.Journal of negative results in biomedicine · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigates the potential of green tea to modulate oxidative stress and angiotensin II AT(1) receptor expression in renal and hepatic tissues of diabetic rats. Three groups of rats were studied after 8 weeks following diabetes induction: normal, streptozotocin-induced diabetic (diabetic control), and green-tea-treated diabetic rats. Total antioxidant, catalase, and malondialdehyde levels were assayed by standard procedures. Levels of AT(1) receptor labeling, in renal and hepatic tissues of the three rat groups, were immunohistochemically investigated using an anti-AT(1) receptor antibody. Levels of total antioxidant and catalase were significantly reduced, whereas malondialdehyde levels and AT(1) receptor labeling were significantly increased in renal and hepatic tissues of diabetic control rats compared to normal rats. Compared to diabetic control rats, total antioxidant and catalase levels were significantly increased, whereas malondialdehyde levels and AT(1) receptor labeling in the green-tea-treated diabetic group were significantly reduced throughout hepatic lobules and renal cortical and medullary vascular and tubular segments to levels comparable to those observed in normal rats. The capacity of green tea to modulate diabetes-induced oxidative stress and AT(1) receptor upregulation may be beneficial in opposing the deleterious effects of excessive angiotensin II signaling, manifested by progressive renal and hepatic tissue damage.
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Registered trials
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