ArticleEvidence-based complementary and alternative medicine : eCAM2012
Balanophora spicata and Lupeol Acetate Possess Antinociceptive and Anti-Inflammatory Activities In Vivo and In Vitro.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- GC-MS-Identified Alkamides and Evaluation of the Anti-Inflammatory, Antibacterial, and Antioxidant Activities of WildInternational journal of molecular sciences · 2025Article
- In-depth analysis of lupeol: delving into the diverse pharmacological profile.Frontiers in pharmacology · 2024Review
- Anti-inflammatory effect of a triterpenoid fromHeliyon · 2022Article
- Anti-inflammatory effects of Chrysophyllum cainito fruit extract in lipopolysaccharide-stimulated mouse peritoneal macrophages.Inflammopharmacology · 2021Article
- Article
- Polysaccharides derived from Balanophora polyandra significantly suppressed the proliferation of ovarian cancer cells through P53-mediated pathway.Journal of cellular and molecular medicine · 2020Article
- Antinociceptive Action ofBalkan medical journal · 2020Article
- Characterization and Cytotoxicity Assessment of the Lipophilic Fractions of Different Morphological Parts ofInternational journal of molecular sciences · 2020Article
- Hepatoprotective and Anti-Inflammatory Activities of theEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis.Oxidative medicine and cellular longevity · 2016Article
- Parkia speciosa Hassk.: A Potential Phytomedicine.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Anti-Inflammatory Effects and Mechanisms of Fatsia polycarpa Hayata and Its Constituents.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Isolation of lupeol acetate from fruit peels ofJournal of advanced pharmaceutical technology & researchArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aims of the present study were to investigate effects of Balanophora spicata (BS) on antinociception and anti-inflammation both in vivo and in vitro. Crude extract of BS inhibited vascular permeability induced by histamine, serotonin, bradykinin, and PGE(2), but not by PAF. Furthermore, BS crude extract, different layers (n-hexane, ethyl acetate, n-butanol, and water layer), and lupeol acetate had significant antinociceptive and anti-inflammatory effects on acetic acid-induced abdominal writhing response, formalin-induced licking behavior, carrageenan-, and serotonin-induced paw edema. The n-hexane layer had the most effective potency among all layers (IC50: 67.33 mg/kg on writhing response; IC50s: 34.2 mg/kg and 21.29 mg/kg on the early phase and late phase of formalin test, resp.). Additionally, lupeol acetate which was isolated from the n-hexane layer of BS effectively inhibited the acetic acid-induced writhing response (IC50: 28.32 mg/kg), formalin-induced licking behavior (IC50: 20.95 mg/kg), NO production (IC50: 4.102 μM), iNOS expression (IC50: 5.35 μM), and COX2 expression (IC50: 5.13 μM) in LPS-stimulated RAW 264.7 cells. In conclusion, BS has antinociceptive and anti-inflammatory effects which may be partially due to the inhibition of changes in vascular permeability induced by histamine, serotonin, bradykinin, and PGE(2) and the attenuation of iNOS and COX-2 expression.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.