ArticleGastroenterology research and practice2012
Urine Metabolite Profiling of Human Colorectal Cancer by Capillary Electrophoresis Mass Spectrometry Based on MRB.
Article in Gastroenterology research and practice, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Nuclear Magnetic Resonance metabolomics reveals an excretory metabolic signature of renal cell carcinoma.Scientific reports · 2016Trial
- Global untargeted and individual targeted plasma metabolomics of breast cancer recurrence modified by hormone receptors.Breast cancer (Tokyo, Japan) · 2024Article
- Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia.Metabolites · 2022Review
- Effects of bowel preparation on intestinal bacterial associated urine and faecal metabolites and the associated faecal microbiome.BMC gastroenterology · 2022Article
- A metagenome-wide association study of the gut microbiota in recurrent aphthous ulcer and regulation by thalidomide.Frontiers in immunology · 2022Article
- Comprehensive Volatilome and Metabolome Signatures of Colorectal Cancer in Urine: A Systematic Review and Meta-Analysis.Cancers · 2021Review
- Capillary Electrophoresis-Mass Spectrometry for Cancer Metabolomics.Advances in experimental medicine and biology · 2021Article
- Metabolomic Comparison of Patients With Colorectal Cancer at Different Anticancer Treatment Stages.Frontiers in oncology · 2021Article
- Resistance to lean mass gain in constitutional thinness in free-living conditions is not overpassed by overfeeding.Journal of cachexia, sarcopenia and muscle · 2020Article
- Metabolomics Analysis of Laparoscopic Surgery Combined with Wuda Granule to Promote Rapid Recovery of Patients with Colorectal Cancer Using UPLC/Q-TOF-MS/MS.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Simultaneous Determination of 34 Amino Acids in Tumor Tissues from Colorectal Cancer Patients Based on the Targeted UHPLC-MS/MS Method.Journal of analytical methods in chemistry · 2020Article
- Review and Comparison of Cancer Biomarker Trends in Urine as a Basis for New Diagnostic Pathways.Cancers · 2019Review
- Urine-NMR metabolomics for screening of advanced colorectal adenoma and early stage colorectal cancer.Scientific reports · 2019Article
- Metabolomics Profiling on Different Stages of Colorectal Cancer: A Systematic Review.The Malaysian journal of medical sciences : MJMS · 2018Review
- Review
- Associations of branched-chain amino acids with parameters of energy balance and survival in colorectal cancer patients: Results from the ColoCare Study.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Serum metabolomics analysis for early detection of colorectal cancer.Journal of gastroenterology · 2017Article
- Correlation analysis of urine metabolites and clinical staging in patients with ovarian cancer.International journal of clinical and experimental medicine · 2015Article
- Metabolomics for biomarker discovery in gastroenterological cancer.Metabolites · 2014Article
- Blood volatile compounds as biomarkers for colorectal cancer.Cancer biology & therapy · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim. The study was to investigate the metabolic profile of urine metabolites and to elucidate their clinical significance in patients with colorectal cancer. Methods. Colorectal cancers from early stage and advanced stage were used in this study. Urine samples of colorectal cancer patients and healthy adults were collected and subjected to capillary electrophoresis mass spectrometry based on moving reaction boundary analysis. The metabolic data were analyzed by SPSS 17.0 to find urinary biomarkers for colorectal cancer. Results. The results indicated that the urine metabolic profiling of colorectal cancer patients had significant changes compared with the normal controls, and there were also differences between early stage and advanced colorectal cancer patients. Compared with the control group, the levels of isoleucine, valine, arginine, lactate acid and leucine increased (P < 0.05), but those of histidine, methionine, serine, aspartic acid, citric acid, succinate, and malic acid decreased in urine samples from colorectal cancer (P < 0.05). Furthermore, the levels of isoleucine and valine were lower in urine of patients with advanced colorectal cancer than those in early stage colorectal cancer (P < 0.05). Conclusion. The technique of capillary electrophoresis mass spectrometry based on MRB could reveal the significant metabolic alterations during progression of colorectal cancer, and the method is feasible and may be useful for the early diagnosis of colorectal cancer.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.