ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2012
Lower frequency of obstructive sleep apnea in spondyloarthritis patients taking TNF-inhibitors.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02438137 (A Randomized Clinical Trial of Dimethyl Fumarate as a Novel Therapeutic Agent for Obstructive Sleep Apnea), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Clinical Trial of Dimethyl Fumarate as a Novel Therapeutic Agent for Obstructive Sleep Apnea
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Pooled it
- Association between tumor necrosis factor alpha and obstructive sleep apnea in adults: a meta-analysis update.BMC pulmonary medicine · 2020Pooled it
- Tumor necrosis factor alpha is a promising circulating biomarker for the development of obstructive sleep apnea syndrome: a meta-analysis.Oncotarget · 2017Pooled it
- Review
- The interconnection between obstructive sleep apnoea and spondyloarthritis: pathophysiology, clinical evidence, and future perspectives.Rheumatology international · 2026Review
- IL-1b and TNF-a-driven sleep alterations: Neuroimmune mechanisms and behavioral implications.Brain, behavior, & immunity - health · 2025Review
- Simple Novel Screening Tool for Obstructive Sleep Apnea in Inflammatory Bowel Disease.Crohn's & colitis 360 · 2023Article
- The effect of continuous positive airway pressure treatment on inflammatory parameters and periostin levels in patients with obstructive sleep apnea syndrome.Sleep & breathing = Schlaf & Atmung · 2023Article
- High-quality and anti-inflammatory diets and a healthy lifestyle are associated with lower sleep apnea risk.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Prevalence of sleep disturbance and the association between poor disease control in people with ankylosing spondylitis within the Australian clinical setting (ASLEEP study): a real-world observational study using the OPAL dataset.Clinical rheumatology · 2022Observational
- Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?Pharmaceuticals (Basel, Switzerland) · 2020Review
- Obstructive sleep apnea and the metabolic syndrome: The road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment.Sleep medicine reviews · 2018Review
- Evaluation of the comorbidity burden in patients with ankylosing spondylitis using a large US administrative claims data set.Clinical rheumatology · 2018Article
- Increased inflammation from childhood to adolescence predicts sleep apnea in boys: A preliminary study.Brain, behavior, and immunity · 2017Article
- Pulmonary, renal and neurological comorbidities in patients with ankylosing spondylitis; implications for clinical practice.Current rheumatology reports · 2014Review
- Pathogenic roles of the carotid body inflammation in sleep apnea.Mediators of inflammation · 2014Review
- Obstructive sleep apnea and autoimmune disease: a two-way process.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2013Article
- Putative associations between inflammatory biomarkers, obesity, and obstructive sleep apnea.Annals of thoracic medicineArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesSleep disturbances, including obstructive sleep apnea (OSA), commonly limit function and quality of life in people with spondyloarthritis (SpA). Systemic inflammation has been implicated in the pathophysiology of both OSA and SpA, and suppression of inflammation with tumor necrosis factor α (TNF) inhibitors may decrease OSA severity. In this study, we compared the frequency of OSA in patients receiving and not receiving TNF-inhibitor therapy.
methodsData were collected from 63 consecutively screened veterans with SpA. Participant interviews, examinations, chart reviews, and referrals to the Salt Lake City Veteran Affairs (SLCVA) Sleep Center were used to obtain demographic data, comorbidities, SpA features, therapy data, and sleep study outcomes.
resultsOSA occurred in 76% of SpA patients. OSA was less common in patients receiving TNF-inhibitor therapy (57%), compared to patients not receiving TNF-inhibitor therapy (91%) (p = 0.01).
conclusionsOSA is underrecognized in veterans with SpA, and TNF-inhibition was associated with a lower frequency of OSA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.