ArticleCirculation research2013
β-Adrenergic regulation of cardiac progenitor cell death versus survival and proliferation.
Article in Circulation research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 65 citations in OpenAlex.
- Cardiac Progenitor Cell Metabolism.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Particulate matter air pollutants and cardiovascular disease: Strategies for intervention.Pharmacology & therapeutics · 2021Review
- Uncoupling protein 2-mediated metabolic adaptations define cardiac cell function in the heart during transition from young to old age.Stem cells translational medicine · 2021Article
- Review
- BNIP3L/NIX and FUNDC1-mediated mitophagy is required for mitochondrial network remodeling during cardiac progenitor cell differentiation.Autophagy · 2019Article
- Transient Introduction of miR-294 in the Heart Promotes Cardiomyocyte Cell Cycle Reentry After Injury.Circulation research · 2019Article
- In situ transcriptome characteristics are lost following culture adaptation of adult cardiac stem cells.Scientific reports · 2018Article
- Cardiac Progenitor Cells: The Matrix Has You.Stem cells translational medicine · 2018Article
- Modulation of cardiac stem cell characteristics by metoprolol in hypertensive heart disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Pathologic Stimulus Determines Lineage Commitment of Cardiac C-kitCirculation · 2017Article
- Management of Chronic Obstructive Pulmonary Disease in Patients with Cardiovascular Diseases.Drugs · 2017Review
- Β-blockers treatment of cardiac surgery patients enhances isolation and improves phenotype of cardiosphere-derived cells.Scientific reports · 2016Article
- Sphingosine 1-phosphate elicits RhoA-dependent proliferation and MRTF-A mediated gene induction in CPCs.Cellular signalling · 2016Article
- Overexpression of the β2AR gene improves function and re-endothelialization capacity of EPCs after arterial injury in nude mice.Stem cell research & therapy · 2016Article
- ADRB2 polymorphisms predict the risk of myocardial infarction and coronary artery disease.Genetics and molecular biology · 2015Article
- Nuclear Calcium/Calmodulin-dependent Protein Kinase II Signaling Enhances Cardiac Progenitor Cell Survival and Cardiac Lineage Commitment.The Journal of biological chemistry · 2015Article
- Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy.Cell stem cell · 2015Article
- Effects of physiologic mechanical stimulation on embryonic chick cardiomyocytes using a microfluidic cardiac cell culture model.Analytical chemistry · 2015Article
- Stimulating endogenous cardiac repair.Frontiers in cell and developmental biology · 2015Review
- Multipotent stem cells of the heart-do they have therapeutic promise?Frontiers in physiology · 2015Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
rationaleShort-term β-adrenergic stimulation promotes contractility in response to stress but is ultimately detrimental in the failing heart because of accrual of cardiomyocyte death. Endogenous cardiac progenitor cell (CPC) activation may partially offset cardiomyocyte losses, but consequences of long-term β-adrenergic drive on CPC survival and proliferation are unknown.
objectiveWe sought to determine the relationship between β-adrenergic activity and regulation of CPC function. METHODS AND
resultsMouse and human CPCs express only β2 adrenergic receptor (β2-AR) in conjunction with stem cell marker c-kit. Activation of β2-AR signaling promotes proliferation associated with increased AKT, extracellular signal-regulated kinase 1/2, and endothelial NO synthase phosphorylation, upregulation of cyclin D1, and decreased levels of G protein-coupled receptor kinase 2. Conversely, silencing of β2-AR expression or treatment with β2-antagonist ICI 118, 551 impairs CPC proliferation and survival. β1-AR expression in CPC is induced by differentiation stimuli, sensitizing CPC to isoproterenol-induced cell death that is abrogated by metoprolol. Efficacy of β1-AR blockade by metoprolol to increase CPC survival and proliferation was confirmed in vivo by adoptive transfer of CPC into failing mouse myocardium.
conclusionsβ-adrenergic stimulation promotes expansion and survival of CPCs through β2-AR, but acquisition of β1-AR on commitment to the myocyte lineage results in loss of CPCs and early myocyte precursors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.