ArticleThe Plant cell2012
Relocalization of late blight resistance protein R3a to endosomal compartments is associated with effector recognition and required for the immune response.
Article in The Plant cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 96 citations in OpenAlex.
- Dissection of Cell Death Induction byLife (Basel, Switzerland) · 2026Article
- Gpa2 detects the potato cyst nematode effector GpRBP-1 in the cytoplasm but requires a balanced nucleocytoplasmic distribution to trigger cell death.Journal of experimental botany · 2025Article
- Live-cell RNA imaging with the inactivated endonuclease Csy4 enables new insights into plant virus transport through plasmodesmata.PLoS pathogens · 2025Article
- A conserved oomycete effector RxLR23 triggers plant defense responses by targeting ERD15La to release NbNAC68.Nature communications · 2024Article
- The maize ZmVPS23-like protein relocates the nucleotide-binding leucine-rich repeat protein Rp1-D21 to endosomes and suppresses the defense response.The Plant cell · 2023Article
- A single region of the Phytophthora infestans avirulence effector Avr3b functions in both cell death induction and plant immunity suppression.Molecular plant pathology · 2023Article
- The endosome as an effector target to mediate plant immunity?Journal of experimental botany · 2023Article
- Grapevine VaRPP13 protein enhances oomycetes resistance by activating SA signal pathway.Plant cell reports · 2022Article
- Article
- Dynamic localization of a helper NLR at the plant-pathogen interface underpins pathogen recognition.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Potato StMPK7 is a downstream component of StMKK1 and promotes resistance to the oomycete pathogen Phytophthora infestans.Molecular plant pathology · 2021Article
- Volatile Compounds FromFrontiers in microbiology · 2021Article
- Endomembrane-TargetingFrontiers in microbiology · 2021Article
- Functional analysis of RXLR effectors from the New Zealand kauri dieback pathogen Phytophthora agathidicida.Molecular plant pathology · 2020Article
- Organize, Don't Agonize: Strategic Success ofMicroorganisms · 2020Review
- Blast resistance gene Pi54 over-expressed in rice to understand its cellular and sub-cellular localization and response to different pathogens.Scientific reports · 2020Article
- AVR2 Targets BSL Family Members, Which Act as Susceptibility Factors to Suppress Host Immunity.Plant physiology · 2019Article
- Phytophthora infestans RXLR effectors act in concert at diverse subcellular locations to enhance host colonization.Journal of experimental botany · 2019Article
- Plant pathogen effector utilizes host susceptibility factor NRL1 to degrade the immune regulator SWAP70.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Disease Resistance Mechanisms in Plants.Genes · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
An important objective of plant-pathogen interactions research is to determine where resistance proteins detect pathogen effectors to mount an immune response. Many nucleotide binding-Leucine-rich repeat (NB-LRR) resistance proteins accumulate in the plant nucleus following effector recognition, where they initiate the hypersensitive response (HR). Here, we show that potato (Solanum tuberosum) resistance protein R3a relocates from the cytoplasm to endosomal compartments only when coexpressed with recognized Phytophthora infestans effector form AVR3a(KI) and not unrecognized form AVR3a(EM). Moreover, AVR3a(KI), but not AVR3a(EM), is also relocalized to endosomes in the presence of R3a. Both R3a and AVR3a(KI) colocalized in close physical proximity at endosomes in planta. Treatment with brefeldin A (BFA) or wortmannin, inhibitors of the endocytic cycle, attenuated both the relocalization of R3a to endosomes and the R3a-mediated HR. No such effect of these inhibitors was observed on HRs triggered by the gene-for-gene pairs Rx1/PVX-CP and Sto1/IpiO1. An R3a(D501V) autoactive MHD mutant, which triggered HR in the absence of AVR3a(KI), failed to localize to endosomes. Moreover, BFA and wortmannin did not alter cell death triggered by this mutant. We conclude that effector recognition and consequent HR signaling by NB-LRR resistance protein R3a require its relocalization to vesicles in the endocytic pathway.
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