ArticleDocumenta ophthalmologica. Advances in ophthalmology2013
Cobalt-chromium toxic retinopathy case study.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- A Systematic Review of Systemic Cobaltism After Wear or Corrosion of Chrome-Cobalt Hip Implants.Journal of patient safety · 2019Pooled it
- The effect of cobalt on the human eye.Documenta ophthalmologica. Advances in ophthalmology · 2015Pooled it
- Cobalt-induced Retinopathy: Unveiling the hidden risk of knee prosthesis.American journal of ophthalmology case reports · 2025Article
- Trace Element Concentration in the Blood and Aqueous Humor of Subjects with Eye Cataract.Biological trace element research · 2025Article
- In Vivo Imaging of Cobalt-Induced Ocular Toxicity in a Mouse Model.Methods and protocols · 2025Article
- Cobalt Toxicity Presenting as Bilateral Optic Neuropathy.Ochsner journal · 2025Article
- An unexpected retained metallic intraocular foreign body.Documenta ophthalmologica. Advances in ophthalmology · 2024Article
- Cobalt Toxicity Induces Retinopathy and Optic Neuropathy in Mice.Investigative ophthalmology & visual science · 2024Article
- An Update Overview on Mechanistic Data and Biomarker Levels in Cobalt and Chromium-Induced Neurodegenerative Diseases.Biological trace element research · 2024Review
- Serum cobalt and chromium concentration following total hip arthroplasty: a Bayesian network meta-analysis.Scientific reports · 2023Article
- Prosthetic hip-associated cobalt toxicity: a systematic review of case series and case reports.EFORT open reviews · 2022Review
- Implant-derived CoCrMo alloy nanoparticle disrupts DNA replication dynamics in neuronal cells.Cell biology and toxicology · 2021Article
- Cobalt toxic optic neuropathy and retinopathy: Case report and review of the literature.American journal of ophthalmology case reports · 2020Article
- Cobalt cardiomyopathy in hip arthroplasty.Arthroplasty today · 2019Article
- Concordance between laboratories in metal ion testing in patients with metal-on-metal hip implants.Canadian journal of surgery. Journal canadien de chirurgie · 2019Article
- Systemic and local toxicity of metal debris released from hip prostheses: A review of experimental approaches.Nanomedicine : nanotechnology, biology, and medicine · 2018Review
- Total hip arthroplasty and cardiovascular complications: a review.Therapeutics and clinical risk management · 2018Review
- The Protective Role of Hyaluronic Acid in Cr(VI)-Induced Oxidative Damage in Corneal Epithelial Cells.Journal of ophthalmology · 2017Article
- Cobalt-Chromium Metallosis With Normal Electroretinogram.Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society · 2016Article
- Cardiac cobaltism: a rare complication after bilateral metal-on-metal total hip arthroplasty.Arthroplasty today · 2015Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo report the clinical case of a 65-year-old male who developed retinal dysfunction following cobalt-chromium toxicity.
methodsA review of the clinical, haematological, radiological and electrophysiological investigations into a single patient was performed in order to form a case report.
resultsA 65-year-old male presented to his ophthalmologist with a 1-year history of worsening vision on the background of a multisystem illness including motor axonopathy, pericardiomyopathy and bulbar palsy. His medical history included hypertension, hypercholesterolaemia and a metallic hip prosthesis. Ocular examination revealed significantly reduced visual acuity bilaterally along with very poor colour vision. Cornea, fundi and optic discs all appeared normal. Bilateral moderate nuclear sclerosis was noted. Basic investigations including mitochondrial studies, auto-immune screen and MRI of brain were unremarkable. Further investigations showed significantly elevated plasma cobalt and chromium levels. Electrophysiological studies revealed an abnormality in all phases of the ERG including a negative b-waveform, suggestive of inner retinal pathology. Following subsequent revision of the hip, cobalt and chromium levels decreased and the patient's vision improved. Further electrophysiological testing indicates a persistent ERG abnormality despite a significant improvement in both the patient's visual acuity and colour vision.
conclusionsThese results suggest that cobalt-chromium toxicity can cause inner retinal dysfunction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.