ArticleNeurochemical research2013
The protective effects of Achyranthes bidentata polypeptides on rat sciatic nerve crush injury causes modulation of neurotrophic factors.
Article in Neurochemical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Pooled it
- Neuroprotective Effect of Natural Products on Peripheral Nerve Degeneration: A Systematic Review.Neurochemical research · 2016Pooled it
- Low-intensity pulsed ultrasound for regenerating peripheral nerves: potential for penile nerve.Asian journal of andrologyPooled it
- Effects and molecular mechanisms ofFrontiers in pharmacology · 2025Review
- Molecular Mechanism of Action of Low-Intensity Extracorporeal Shockwave Therapy for Regenerating Penile and Peripheral Nerves.Turkish journal of urology · 2022Article
- The Impact of Supplements on Recovery After Peripheral Nerve Injury: A Review of the Literature.Cureus · 2022Review
- Identification of Neuronal Cells in Sciatic Nerves of Adult Rats.Frontiers in cellular neuroscience · 2022Article
- Revisiting the Role of Biologically Active Natural and Synthetic Compounds as an Intervention to Treat Injured Nerves.Molecular neurobiology · 2021Review
- Bidentatide, a Novel Plant Peptide Derived fromInternational journal of molecular sciences · 2021Article
- Effect of herbal extracts on peripheral nerve regeneration after microsurgery of the sciatic nerve in rats.BMC complementary medicine and therapies · 2021Article
- The complete chloroplast genome ofMitochondrial DNA. Part B, Resources · 2021Article
- Protective effects and molecular mechanisms ofAnnals of translational medicine · 2021Article
- Effect of ethanolic extract of Solanum virginianum Linn. on neuropathic pain using chronic constriction injury rat model and molecular docking studies.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Exosome Released From Schwann Cells May Be Involved in Microenergy Acoustic Pulse-Associated Cavernous Nerve Regeneration.The journal of sexual medicine · 2020Article
- Comparing and phylogenetic analysis chloroplast genome of three Achyranthes species.Scientific reports · 2020Article
- Dexmedetomidine Improves Locomotor Function and Alleviates Thermal Hyperalgesia Following Sciatic Nerve Crush Injury in Rats.International neurourology journal · 2020Article
- Article
- Achyranthes bidentata polypeptide protects dopaminergic neurons from apoptosis in Parkinson's disease models both in vitro and in vivo.British journal of pharmacology · 2018Article
- Article
- Tanshinone IIA attenuates nerve structural and functional damage induced by nerve crush injury in rats.PloS one · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharmacological treatment is a therapeutic approach to improving nerve regeneration and functional recovery after peripheral nerve crush injury. The objective of the present study was to investigate the effects of the polypeptides isolated from Achyranthes bidentata Blume (abbreviated as ABPP) on rat sciatic crush injury and to test the possible involvement of neurotrophic factors. After surgical crush injury, rats received daily intraperitoneal injection of 0.2 ml saline containing 2 mg ABPP, 1 μg nerve growth factor (NGF) or no additive. The results from walking track analysis, electrophysiological assessment and histological evaluation indicated that the repair outcomes by ABPP treatment were close to those by NGF treatment, but better than those by treatment with saline alone. The quantitative real-time RT-PCR was used to monitor the mRNA expression of growth associated protein in the crush nerves and the mRNA expression of NGF, brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), tyrosine kinase (Trk)A and TrkB in the dorsal root ganglia (DRGs) at L4-L6. The mRNA expression of these genes in the crush nerve sample and DRGs sample was higher after treatment with ABPP or NGF than after treatment with saline alone. Our findings suggest that ABPP might protect peripheral nerve against crush injury through stimulating release of neurotrophic factors and the other cytokines.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.