ArticleMolecular biology reports2013
Association of LRP5 haplotypes with osteoporosis in Mexican women.
Article in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Association of rs3736228 polymorphism in LRP5 gene with bone fracture and osteoporosis: a systematic review and updated meta-analysis.BMC musculoskeletal disorders · 2026Pooled it
- Common polymorphism in the LRP5 gene may increase the risk of bone fracture and osteoporosis.BioMed research international · 2014Pooled it
- Validation of Osteoporosis associated SNPs candidates from Decisive Gene Strategy using Taiwan Biobank.International journal of medical sciences · 2026Article
- Associations of LRP5 Gene With Bone Mineral Density, Bone Turnover Markers, and Fractures in the Elderly With Osteoporosis.Frontiers in endocrinology · 2020Article
- Associations ofDisease markers · 2019Article
- Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women.PloS one · 2019Observational
- A Pilot Genome-Wide Association Study in Postmenopausal Mexican-Mestizo Women Implicates the RMND1/CCDC170 Locus Is Associated with Bone Mineral Density.International journal of genomics · 2017Article
- Two novel susceptibility loci for non-small cell lung cancer map to low-density lipoprotein receptor-related protein 5.Oncology letters · 2016Article
- LRP receptor family member associated bone disease.Reviews in endocrine & metabolic disorders · 2015Review
- WNT3A gene polymorphisms are associated with bone mineral density variation in postmenopausal mestizo women of an urban Mexican population: findings of a pathway-based high-density single nucleotide screening.Age (Dordrecht, Netherlands) · 2014Article
- Association of LRP5 gene polymorphism with type 2 diabetes mellitus and osteoporosis in postmenopausal women.International journal of clinical and experimental medicine · 2014Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is a common health problem in Mexico, so it is essential to investigate the status of different gene polymorphisms that could serve as genetic susceptibility markers in the Mexican population. Genes with a role in bone metabolism are excellent candidates for association studies. In this study were determined the allelic and genotypic frequencies of four polymorphic markers (C/T rs3736228, G/A rs4988321, T/C rs627174 and T/C rs901824) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) and their association with osteoporosis in 100 pos-menopausal osteoporotic Mexican women and their controls, using real time-PCR and TaqMan probes. Only the G/A polymorphism (rs4988321, Val667Met) showed significant differences (p = 0.039) when genotype frequencies were compared. However, when the haplotypes of these four polymorphisms were analyzed, interesting associations became evident. The CGTT haplotype showed significant association with low risk of osteoporosis (OR 0.629; p = 0.007; [95 % CI, 0.448-0.884]), whereas the TACT haplotype was significantly associated with a higher risk of osteoporosis (OR 7.965; p = 0.006; [95 % CI, 1.557-54.775]). Our results supported the association of LRP5 with osteoporosis and showed the potential value of LRP5 haplotypes to identify risk of osteoporosis in Mexican population.
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