SynthesisJournal of molecular neuroscience : MN2013
Apolipoprotein ε4-allele as a significant risk factor for conversion from mild cognitive impairment to Alzheimer's disease: a meta-analysis of prospective studies.
Synthesis in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of Ubiquilin1 gene polymorphism and Alzheimer's disease risk.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- Feasibility of identifying factors related to Alzheimer's disease and related dementia in real-world data.JAMIA open · 2026Review
- Statistical Method for Identification of Alzheimer Disease With Multimodal Predictive Markers Mild Cognitive Impairment.Basic and clinical neuroscience · 2025Article
- APOEε4 Carriers Exhibit Objective Cognitive Deficits: A Cross-Sectional Study in a Single Center Trial.Brain sciences · 2024Article
- Correlation between theFrontiers in public health · 2024Article
- Incidence and Cognitive Decline of Alzheimer's Disease and Other Dementia by Apolipoprotein ε4 Allele Presence: A Community-Based Cohort Study in Korean Elderly.Psychiatry investigation · 2022Article
- The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk.International journal of molecular sciences · 2019Review
- The Specific Impact of Apolipoprotein E Epsilon 2 on Cognition and Brain Function in Cognitively Normal Elders and Mild Cognitive Impairment Patients.Frontiers in aging neuroscience · 2019Article
- A 'Framingham-like' Algorithm for Predicting 4-Year Risk of Progression to Amnestic Mild Cognitive Impairment or Alzheimer's Disease Using Multidomain Information.Journal of Alzheimer's disease : JAD · 2018Article
- Associations between APOE polymorphisms and seven diseases with cognitive impairment including Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies in southeast China.Psychiatric genetics · 2016Article
- Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
- Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease.JAMA neurology · 2016Article
- Alzheimer's Disease Genetic Risk Factor APOE-ε4 Also Affects Normal Brain Function.Current Alzheimer research · 2016Review
- Apolipoprotein E (ApoE) polymorphism is related to differences in potential fertility in women: a case of antagonistic pleiotropy?Proceedings. Biological sciences · 2015Article
- Associations between apolipoprotein E gene polymorphisms and Alzheimer's disease risk in a large Chinese Han population.Clinical interventions in aging · 2015Article
- Novel mutations in the amyloid precursor protein gene within Moroccan patients with Alzheimer's disease.Journal of molecular neuroscience : MN · 2014Article
- A combined effect of two Alzheimer's risk genes on medial temporal activity during executive attention in young adults.Neuropsychologia · 2014Article
- Two Alzheimer's disease risk genes increase entorhinal cortex volume in young adults.Frontiers in human neuroscience · 2014Article
- Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study.Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies of the relationship between progression from mild cognitive impairment (MCI) to Alzheimer disease (AD) and APOE ε4-allele revealed inconsistent results. To estimate the risk posed by APOE ε4-allele for developing AD in MCI subjects using meta-analysis and identify possible sources of heterogeneity between studies, we reviewed longitudinal epidemiological studies of the presence of APOE ε4-allele on risk for progression to dementia in MCI subjects, and conducted meta-analyses of the results from these studies. Our study was derived from 315 positive-outcome events and 461 negative-outcome events from 8 prospective studies. The pooled RR was statistically significant (pooled RR = 2.09; 95 % CI, 1.52-2.88). The Q statistics indicated high heterogeneity across studies (Q = 14.21, p = 0.003). RR were significantly related to the ethnicity of the sample (z = 3.58, p = 0.024). No significant heterogeneity was observed after stratification in four European-population studies (χ² = 0.67, p = 0.880), but it remained in four American-population studies (χ² = 18.52, p = 0.003). Heterogeneity markedly reduced after excluding one specific study (Q = 4.9, p = 0.009; I² = 39 %). APOE ε4-allele conferred increased risk for progression to dementia in MCI subjects. Ethnicity is a critical factor to yield heterogeneity. Further studies using larger sample sizes are required.
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