ArticleMolecular & cellular proteomics : MCP2013
Matrix assisted ionization vacuum (MAIV), a new ionization method for biological materials analysis using mass spectrometry.
Article in Molecular & cellular proteomics : MCP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Multi-Port Vacuum Assembly Device Designed for Simplified Point-of-Need Chemical and Biological Analyses Using Mass Spectrometry.Analytical chemistry · 2026Article
- New Processes for Ionizing Nonvolatile Compounds in Mass Spectrometry: The Road of Discovery to Current State-of-the-Art.Journal of the American Society for Mass Spectrometry · 2024Review
- Direct sub-atmospheric pressure ionization mass spectrometry: Evaporation/sublimation-driven ionization is amazing, fundamentally, and practically.Journal of mass spectrometry : JMS · 2024Review
- Instrumentation development, improvement, simplification, and miniaturization: The multifunctional plate source for use in mass spectrometry.European journal of mass spectrometry (Chichester, England) · 2023Article
- ADVANCES IN HIGH-RESOLUTION MALDI MASS SPECTROMETRY FOR NEUROBIOLOGY.Mass spectrometry reviews · 2022Review
- Fundamental Studies of New Ionization Technologies and Insights from IMS-MS.Journal of the American Society for Mass Spectrometry · 2019Article
- Ambient Profiling of Phenolic Content in Tea Infusions by Matrix-Assisted Ionization in Vacuum.Journal of the American Society for Mass Spectrometry · 2018Article
- A high resolution atmospheric pressure matrix-assisted laser desorption/ionization-quadrupole-orbitrap MS platform enables in situ analysis of biomolecules by multi-mode ionization and acquisition.Analytica chimica acta · 2018Article
- Spontaneous Charge Separation and Sublimation Processes are Ubiquitous in Nature and in Ionization Processes in Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2018Article
- Coupling matrix-assisted ionization with high resolution mass spectrometry and electron transfer dissociation to characterize intact proteins and post-translational modifications.Analytical and bioanalytical chemistry · 2018Article
- Matrix-Assisted Ionization on a Portable Mass Spectrometer: Analysis Directly from Biological and Synthetic Materials.Analytical chemistry · 2016Article
- High Sensitivity Analysis of Nanoliter Volumes of Volatile and Nonvolatile Compounds using Matrix Assisted Ionization (MAI) Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- Rapid high mass resolution mass spectrometry using matrix-assisted ionization.Methods (San Diego, Calif.) · 2016Article
- Matrix-assisted ionization vacuum for protein detection, fragmentation and PTM analysis on a high resolution linear ion trap-orbitrap platform.Analytica chimica acta · 2016Article
- "Magic" Ionization Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2016Article
- High Throughput In Situ DDA Analysis of Neuropeptides by Coupling Novel Multiplex Mass Spectrometric Imaging (MSI) with Gas-Phase Fractionation.Journal of the American Society for Mass Spectrometry · 2015Article
- Matrix-Assisted Ionization-Ion Mobility Spectrometry-Mass Spectrometry: Selective Analysis of a Europium-PEG Complex in a Crude Mixture.Journal of the American Society for Mass Spectrometry · 2015Article
- Improving the Sensitivity of Matrix-Assisted Ionization (MAI) Mass Spectrometry Using Ammonium Salts.Journal of the American Society for Mass Spectrometry · 2015Article
- Drug detection and quantification directly from tissue using novel ionization methods for mass spectrometry.European journal of mass spectrometry (Chichester, England) · 2015Article
- Transmission geometry laserspray ionization vacuum using an atmospheric pressure inlet.Analytical chemistry · 2014Article
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Authors and funding
2 authors.
Funding
Abstract
The introduction of electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) for the mass spectrometric analysis of peptides and proteins had a dramatic impact on biological science. We now report that a wide variety of compounds, including peptides, proteins, and protein complexes, are transported directly from a solid-state small molecule matrix to gas-phase ions when placed into the vacuum of a mass spectrometer without the use of high voltage, a laser, or added heat. This ionization process produces ions having charge states similar to ESI, making the method applicable for high performance mass spectrometers designed for atmospheric pressure ionization. We demonstrate highly sensitive ionization using intermediate pressure MALDI and modified ESI sources. This matrix and vacuum assisted soft ionization method is suitable for the direct surface analysis of biological materials, including tissue, via mass spectrometry.
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