ArticleThe Journal of infectious diseases2013
A cohort effect of the sexual revolution may be masking an increase in human papillomavirus detection at menopause in the United States.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 110 citations in OpenAlex.
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- Anogenital HPV-Related Cancers in Women: Investigating Trends and Sociodemographic Risk Factors.Cancers · 2024Article
- High frequency of alpha7-HPV in Colombian Caribbean coast women: cervical cancer screening analysis.BMC infectious diseases · 2024Article
- Anal Cancer in High-Risk Women: The Lost Tribe.Cancers · 2022Review
- Trends in HPV- and non-HPV-associated vulvar cancer incidence, United States, 2001-2017.Preventive medicine · 2022Article
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- Prevalence of Human Papillomavirus Among Women Older than Recommended Age for Vaccination by Birth Cohort, United States 2003‒2016.The Journal of infectious diseases · 2022Article
- Cutaneous malignant melanoma incidence is strongly associated with European depigmented skin type regardless of ambient ultraviolet radiation levels: evidence from Worldwide population-based data.AIMS public health · 2022Article
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- It's time to re-evaluate cervical Cancer screening after age 65.Gynecologic oncology · 2021Review
- Median Age at HPV Infection Among Women in the United States: A Model-Based Analysis Informed by Real-world Data.Open forum infectious diseases · 2021Article
- The impact of aging on innate and adaptive immunity in the human female genital tract.Aging cell · 2021Review
- Rates of New Human Papillomavirus Detection and Loss of Detection in Middle-aged Women by Recent and Past Sexual Behavior.The Journal of infectious diseases · 2021Article
- The Impact of Human Papillomavirus Infection on Skin Cancer: A Population-Based Cohort Study.The oncologist · 2021Article
- Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundCohort effects, new sex partnerships, and human papillomavirus (HPV) reactivation have been posited as explanations for the bimodal age-specific HPV prevalence observed in some populations; no studies have systematically evaluated the reasons for the lack of a second peak in the United States.
methodsA cohort of 843 women aged 35-60 years were enrolled into a 2-year, semiannual follow-up study. Age-specific HPV prevalence was estimated in strata defined by a lower risk of prior infection (<5 self-reported lifetime sex partners) and a higher risk of prior infection (≥ 5 lifetime sex partners). The interaction between age and lifetime sex partners was tested using likelihood ratio statistics. Population attributable risk (PAR) was estimated using Levin's formula.
resultsThe age-specific prevalence of 14 high-risk HPV genotypes (HR-HPV) declined with age among women with <5 lifetime sex partners but not among women with ≥ 5 lifetime sex partners (P = .01 for interaction). The PAR for HR-HPV due to ≥ 5 lifetime sex partners was higher among older women (87.2%), compared with younger women (28.0%). In contrast, the PAR associated with a new sex partner was 28% among women aged 35-49 years and 7.7% among women aged 50-60 years.
conclusionsA lower cumulative probability of HPV infection among women with a sexual debut before the sexual revolution may be masking an age-related increase in HPV reactivation in the United States.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.