ArticleNature cell biology2013
Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy.
Article in Nature cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- LGL-1 and the RhoGAP protein PAC-1 redundantly polarize thebioRxiv : the preprint server for biology · 2026Article
- Atypical Protein Kinase C Promotes its own Asymmetric Localisation by Phosphorylating Cdc42 in thebioRxiv : the preprint server for biology · 2024Article
- Global analysis of suppressor mutations that rescue human genetic defects.Genome medicine · 2023Article
- Casein kinase 1 gamma regulates oxidative stress response via interacting with the NADPH dual oxidase complex.PLoS genetics · 2023Article
- Aurora A and cortical flows promote polarization and cytokinesis by inducing asymmetric ECT-2 accumulation.eLife · 2022Article
- PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos.The Journal of cell biology · 2022Article
- Balancing cell polarity PARts through dephosphorylation.The Journal of cell biology · 2022Article
- An analog sensitive allele permits rapid and reversible chemical inhibition of PKC-3 activity inmicroPublication biology · 2022Article
- Analysis of Nuclear Pore Complexes in Caenorhabditis elegans by Live Imaging and Functional Genomics.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Going with the flow: insights fromPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- The Role ofGenetics · 2020Article
- Mechanical stress induces a scalable switch in cortical flow polarization during cytokinesis.Journal of cell science · 2019Article
- Article
- Planar Asymmetries in theFrontiers in cell and developmental biology · 2019Article
- Mitotic Cell Division inGenetics · 2019Review
- G Proteins and GPCRs in C. elegans Development: A Story of Mutual Infidelity.Journal of developmental biology · 2018Review
- Article
- 14-3-3εa directs the pulsatile transport of basal factors toward the apical domain for lumen growth in tubulogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A casein kinase 1 prevents expulsion of the oocyte meiotic spindle into a polar body by regulating cortical contractility.Molecular biology of the cell · 2017Article
- aPKC Cycles between Functionally Distinct PAR Protein Assemblies to Drive Cell Polarity.Developmental cell · 2017Article
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9 authors.
Funding
Abstract
Although single-gene loss-of-function analyses can identify components of particular processes, important molecules are missed owing to the robustness of biological systems. Here we show that large-scale RNAi screening for suppression interactions with functionally related mutants greatly expands the repertoire of genes known to act in a shared process and reveals a new layer of functional relationships. We performed RNAi screens for 17 Caenorhabditis elegans cell polarity mutants, generating the most comprehensive polarity network in a metazoan, connecting 184 genes. Of these, 72% were not previously linked to cell polarity and 80% have human homologues. We experimentally confirmed functional roles predicted by the network and characterized through biophysical analyses eight myosin regulators. In addition, we discovered functional redundancy between two unknown polarity genes. Similar systematic genetic interaction screens for other biological processes will help uncover the inventory of relevant genes and their patterns of interactions.
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