Evidence map›Paper›PMID 23242124›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2013

Histone deacetylases enzyme, copper, and IL-8 levels in patients with Alzheimer's disease.

Mohamad A Alsadany, Hanan H Shehata, Magda I Mohamad, Riham G Mahfouz

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 56 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 8 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 8 syntheses or guidelines pooled it, 91 citations in OpenAlex.

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  4. Are high copper levels related to Alzheimer's and Parkinson's diseases? A systematic review and meta-analysis of articles published between 2011 and 2022.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Pooled it
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  6. Association between Periodontal Disease and Cognitive Impairment in Adults.International journal of environmental research and public health · 2023
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  14. Brain interleukins and Alzheimer's disease.Metabolic brain disease · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Mohamad A AlsadanyGeriatrics Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. mohamadalsadany@hotmail.com
Hanan H Shehata
Magda I Mohamad
Riham G Mahfouz
Ain Shams University · EGMenoufia University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of cognitive abilities. Epigenetic modification, oxidative stress, and inflammation play an important role in the pathogenesis of the disease. We aimed to detect noninvasive peripheral biomarkers with a high degree of sensitivity and specificity in diagnosis and progression of AD.

methodsA total of 25 elderly patients with AD and 25 healthy control participants were selected and subjected to cognitive assessment and laboratory measures including histone deacetylases (HDACs), copper, and interleukin 8 (IL-8) levels.

resultsThe levels of HDACs, copper, and IL-8 were significantly higher in patients with AD (P < .001) and had a significant negative effect on all cognitive assessment tests. Receiver-operating curve (ROC) analysis revealed that HDACs and copper levels had higher sensitivity and specificity.

conclusionsPlasma levels of HDACs and copper may be used as peripheral biomarkers in diagnosis of AD, while IL-8 level could be a useful biomarker in following AD progression.

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBiomarkersCognition DisordersCopperDisease ProgressionDown-RegulationFemaleGeriatric AssessmentHistone DeacetylasesHumansInterleukin-8MaleNeuropsychological TestsPsychiatric Status Rating ScalesBiomarkersCopperHistone DeacetylasesInterleukin-8

Identifiers

PMID23242124
PMCPMC10697231
OpenAlexW2120912103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.