ReviewCurrent opinion in allergy and clinical immunology2013
Epigenetic mechanisms and models in the origins of asthma.
Review in Current opinion in allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Evaluating the Influence ofBiomolecules · 2025Article
- Differences in the DNA methylome of T cells in adults with asthma of varying severity.Clinical epigenetics · 2024Article
- Differences in the DNA Methylome of T cells in Adults With Asthma of Varying Severity.Research square · 2024Article
- Identification of candidate aberrant differentially methylated/expressed genes in asthma.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2022Article
- IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma.Journal of immunology research · 2021Article
- Genome‑wide analysis of DNA methylation and gene expression changes in an ovalbumin‑induced asthma mouse model.Molecular medicine reports · 2020Article
- Immunologic and Non-Immunologic Mechanisms Leading to Airway Remodeling in Asthma.International journal of molecular sciences · 2020Review
- Interweaving Between Genetic and Epigenetic Studies on Childhood Asthma.Epigenetics insights · 2020Article
- Role of PCDH 1 Gene in the Development of Childhood Asthma and Other Related Phenotypes: A Literature Review.Cureus · 2018Review
- Unified variable selection in semi-parametric models.Statistical methods in medical research · 2017Article
- Prenatal environmental tobacco smoke exposure increases allergic asthma risk with methylation changes in mice.Environmental and molecular mutagenesis · 2017Article
- Article
- DNA methylation and genetic polymorphisms of the Leptin gene interact to influence lung function outcomes and asthma at 18 years of age.International journal of molecular epidemiology and genetics · 2016Article
- Establishing a birth cohort to investigate the course and aetiology of asthma and allergies across three generations - rationale, design, and methods of the ACROSSOLAR study.BMC public health · 2015Article
- Risk of childhood asthma is associated with CpG-site polymorphisms, regional DNA methylation and mRNA levels at the GSDMB/ORMDL3 locus.Human molecular genetics · 2015Article
- Fast food fever: reviewing the impacts of the Western diet on immunity.Nutrition journal · 2014Review
- Asthma genetics and personalised medicine.The Lancet. Respiratory medicine · 2014Review
- Asthma, allergy, and responses to methyl donor supplements and nutrients.The Journal of allergy and clinical immunology · 2014Review
- Environmental epigenetics and effects on male fertility.Advances in experimental medicine and biology · 2014Review
- Oral contraceptives modify the effect of GATA3 polymorphisms on the risk of asthma at the age of 18 years via DNA methylation.Clinical epigenetics · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purpose of reviewEpigenetic mechanisms have the ability to alter the phenotype without changing the genetic code. The science of epigenetics has grown considerably in recent years, and future epigenetically based treatments or prevention strategies are likely. Epigenetic associations with asthma have received growing interest because genetic and environmental factors have been unable to independently explain the cause of asthma. RECENT
findingsRecent findings suggest that both the environment and underlying genetic sequence variation influence DNA methylation, which in turn seems to modify the risk conferred by genetic variants for various asthma phenotypes. In particular, DNA methylation may act as an archive of a variety of early developmental exposures, which then can modify the risk related to genetic variants. SUMMARY: Current asthma treatments may control the symptoms of asthma but do not modify its natural history. Epigenetic mechanisms and novel explanatory models provide burgeoning approaches to significantly increase our understanding of the initiation and progression of asthma. Due to the inheritance of epigenetics, we anticipate a rapid emergence of critical information that will provide novel treatment strategies for asthma in the current generation and ultimately the prevention of asthma in future generations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.