ArticleJournal of visualized experiments : JoVE2012
Methods for intravenous self administration in a mouse model.
Article in Journal of visualized experiments : JoVE, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- A widespread internal brain state for fentanyl withdrawal.bioRxiv : the preprint server for biology · 2026Article
- Formation of an Enduring Ensemble of Accumbens Neurons Leads to Prepotent Seeking for Cocaine Over Natural Reward Cues.bioRxiv : the preprint server for biology · 2024Article
- Article
- Kappa-opioid receptor activation reinstates nicotine self-administration in mice.Addiction neuroscience · 2022Article
- Animal Models to Investigate the Impact of Flavors on Nicotine Addiction and Dependence.Current neuropharmacology · 2022Review
- Jugular Vein Catheter Design and Cocaine Self-Administration Using Mice: A Comprehensive Method.Frontiers in behavioral neuroscience · 2022Article
- Combined implanted central venous access and cortical recording electrode array in freely behaving mice.MethodsX · 2021Article
- Sex chromosome complement influences vulnerability to cocaine in mice.Hormones and behavior · 2020Article
- β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.Cell · 2020Article
- Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction.Nature communications · 2019Article
- Male and female mice develop escalation of heroin intake and dependence following extended access.Neuropharmacology · 2019Article
- Blood collection in unstressed, conscious, and freely moving mice through implantation of catheters in the jugular vein: a new simplified protocol.Physiological reports · 2018Article
- A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder.Journal of visualized experiments : JoVE · 2018Article
- Article
- Optoanesthesia: Use of Anesthetic Photolabels In Vivo.Methods in enzymology · 2018Article
- Intravenous self-administration of alcohol in rats-problems with translation to humans.Addiction biology · 2017Review
- G Protein-Gated Potassium Channels: A Link to Drug Addiction.Trends in pharmacological sciences · 2017Review
- Reversal of Cytosolic One-Carbon Flux Compensates for Loss of the Mitochondrial Folate Pathway.Cell metabolism · 2016Article
- Association of novelty-related behaviors and intravenous cocaine self-administration in Diversity Outbred mice.Psychopharmacology · 2015Article
- Pharmacology and anti-addiction effects of the novel κ opioid receptor agonist Mesyl Sal B, a potent and long-acting analogue of salvinorin A.British journal of pharmacology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Animal models have been developed to study the reinforcing effects of drugs, including the intravenous self-administration (IVSA) paradigm. The advantages of using an IVSA paradigm to study the reinforcing properties of drugs of abuse such as cocaine include the fact that the drug is self-administered instead of experimenter-administered, the schedule of reinforcement can be altered, and accurate measurement of the quantities of drug consumed as well as the timing and pattern of IV injections can be obtained. Furthermore, the intravenous route of administration avoids potential confounds related to first pass metabolism or taste, and produces rapid increases in blood and brain drug levels. As outlined in this video, intravenous self-administration can be obtained without prior food restriction or prior drug training following careful catheter placement during surgery and meticulous daily catheter flushing and maintenance. Experimental procedures outlined in this paper include a description of animal housing and acclimation methods, operant training using sweetened milk solutions, and catheter implantation surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.