ArticleThe Pediatric infectious disease journal2013
Impact of respiratory viral infections on α-hemolytic streptococci and otopathogens in the nasopharynx of young children.
Article in The Pediatric infectious disease journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Article
- Nasopharyngeal colonization with pathobionts is associated with susceptibility to respiratory illnesses in young children.PloS one · 2020Article
- Impaired Proinflammatory Response in Stringently Defined Otitis-prone Children During Viral Upper Respiratory Infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Article
- The role of respiratory viruses in the etiology of bacterial pneumonia: An ecological perspective.Evolution, medicine, and public health · 2016Review
- Adenoidal follicular T helper cells provide stronger B-cell help than those from tonsils.The Laryngoscope · 2016Article
- Familial and microbiological contribution to the otitis-prone condition.International journal of pediatric otorhinolaryngology · 2015Article
- Correlation of nasopharyngeal cultures prior to and at onset of acute otitis media with middle ear fluid cultures.BMC infectious diseases · 2014Article
- Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection.Epidemiology and infection · 2014Article
- Article
- Impact of pneumococcal conjugate vaccines on microbial epidemiology and clinical outcomes of acute otitis media.Paediatric drugs · 2014Article
- The host immune dynamics of pneumococcal colonization: implications for novel vaccine development.Human vaccines & immunotherapeutics · 2014Review
- Cellular immune response in young children accounts for recurrent acute otitis media.Current allergy and asthma reports · 2013Review
- Higher serum levels of interleukin 10 occur at onset of acute otitis media caused by Streptococcus pneumoniae compared to Haemophilus influenzae and Moraxella catarrhalis.The Laryngoscope · 2013Article
- Current concepts in host-microbe interaction leading to pneumococcal pneumonia.Current opinion in infectious diseases · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe studied nasopharyngeal (NP) colonization in a cohort of children to determine the impact of viral upper respiratory infections (URIs) on nonpneumococcal α-hemolytic streptococci (AHS) and otopathogen colonization in association with acute otitis media (AOM).
methodsNP samples were collected routinely when children were aged 6, 9, 12, 15, 18, 24 and 30 months and during episodes of AOM. NP samples were prospectively obtained from 248 children during a 5-year time span: 1018 during routine visits, 161 at the time of AOM and 59 at follow-up visits 3 weeks after AOM.
resultsThe overall NP colonization rate of AHS was 50.8% during a non-AOM visit but declined to 38.3% during a viral URI with concurrent AOM (P = 0.0006). Of 56 AOM visits with paired follow-ups, 6 (10.7%) had AHS in the NP at the time of viral URI and concurrent AOM whereas 29 (51.8%) had AHS at the follow-up (P < 0.001). Lower NP colonization rates with AHS were associated with significant increases in Streptococcus pneumoniae carriage during non-AOM visits (P < 0.001) and during viral URI and concurrent AOM visits (P = 0.003). AHS NP colonization rates were not different when children had a viral URI without AOM versus when they were URI negative, but NP colonization with nontypeable Haemophilus influenzae rates increased (P < 0.001) and Moraxella catarrhalis decreased (P < 0.001) during viral URI.
conclusionRespiratory viral infections alter NP carriage rates of commensal AHS and otopathogens, including before AOM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.