ReviewCalcified tissue international2013
Biomineralization mechanisms: a new paradigm for crystal nucleation in organic matrices.
Review in Calcified tissue international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
44 citing papers in PubMed, 160 citations in OpenAlex.
- Three-Dimensional Characterization of the Collagen-Hydroxyapatite Interaction During Heterotopic Ossification in Healing Rat Achilles Tendons.Small science · 2026Article
- The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation.Nature communications · 2025Article
- Extracellular matrix dysregulation in aging, calcification, and cancer diseases: insights into cellular senescence, inflammation, and novel therapeutic strategies.International journal of biological sciences · 2025Review
- Transcriptome profiling of DPP stimulated DPSCs identifies the role of autophagy in odontogenic differentiation.Journal of structural biology · 2024Article
- One-Pot Hybridization of Microfibrillated Cellulose and Hydroxyapatite as a Versatile Route to Eco-Friendly Mechanical Materials.ACS omega · 2024Article
- Effects of mineralization on the hierarchical organization of collagen-a synchrotron X-ray scattering and polarized second harmonic generation study.Interface focus · 2024Article
- The impact of crystal phase transition on the hardness and structure of kidney stones.Urolithiasis · 2024Article
- A noveliScience · 2024Article
- Non-Specific Inhibition of Dipeptidyl Peptidases 8/9 by Dipeptidyl Peptidase 4 Inhibitors Negatively Affects Mesenchymal Stem Cell Differentiation.Journal of clinical medicine · 2023Article
- A Doubly Fmoc-Protected Aspartic Acid Self-Assembles into Hydrogels Suitable for Bone Tissue Engineering.Materials (Basel, Switzerland) · 2022Article
- Biomineralization of bone tissue: calcium phosphate-based inorganics in collagen fibrillar organic matrices.Biomaterials research · 2022Review
- Hierarchy of Bioapatites.International journal of molecular sciences · 2022Article
- Fluorescence evidence of annexin A6 translocation across membrane in model matrix vesicles during apatite formation.Journal of extracellular biology · 2022Article
- Highly acidic pH facilitates enamel protein self-assembly, apatite crystal growth and enamel protein interactions in the early enamel matrix.Frontiers in physiology · 2022Article
- DPP promotes odontogenic differentiation of DPSCs through NF-κB signaling.Scientific reports · 2021Article
- Biomineralization of Enamel and Dentin Mediated by Matrix Proteins.Journal of dental research · 2021Review
- Article
- Analysis of laboratory adhesion studies in eroded enamel and dentin: a scoping review.Biomaterial investigations in dentistry · 2021Article
- Multiple Pathways for Pathological Calcification in the Human Body.Advanced healthcare materials · 2021Review
- In Vitro Calcification of Bioprosthetic Heart Valves: Test Fluid Validation on Prosthetic Material Samples.Annals of biomedical engineering · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
There is substantial practical interest in the mechanism by which the carbonated apatite of bone mineral can be initiated specifically in a matrix. The current literature is replete with studies aimed at mimicking the properties of vertebrate bone, teeth, and other hard tissues by creating organic matrices that can be mineralized in vitro and either functionally substitute for bone on a permanent basis or serve as a temporary structure that can be replaced by normal remodeling processes. A key element in this is mineralization of an implant with the matrix and mineral arranged in the proper orientations and relationships. This review examines the pathway to crystallization from a supersaturated calcium phosphate solution in vitro, focusing on the basic mechanistic questions concerning mineral nucleation and growth. Since bone and dentin mineral forms within collagenous matrices, we consider how the in vitro crystallization mechanisms might or might not be applicable to understanding the in vivo processes of biomineralization in bone and dentin. We propose that the pathway to crystallization from the calcium phosphate-supersaturated tissue fluids involves the formation of a dense liquid phase of first-layer bound-water hydrated calcium and phosphate ions in which the crystallization is nucleated. SIBLING proteins and their in vitro analogs, such as polyaspartic acids, have similar dense liquid first-layer bound-water surfaces which interact with the dense liquid calcium phosphate nucleation clusters and modulate the rate of crystallization within the bone and dentin collagen fibril matrix.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.