ArticleNucleic acids research2013
A cis-element with mixed G-quadruplex structure of NPGPx promoter is essential for nucleolin-mediated transactivation on non-targeting siRNA stress.
Article in Nucleic acids research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Long promoter sequences form higher-order G-quadruplexes: an integrative structural biology study of c-Myc, k-Ras and c-Kit promoter sequences.Nucleic acids research · 2022Article
- Antisense Oligonucleotides Used to Identify Telomeric G-Quadruplexes in Metaphase Chromosomes and Fixed Cells by Fluorescence Lifetime Imaging Microscopy ofMolecules (Basel, Switzerland) · 2020Article
- Nucleolin represses transcription of the androgen receptor gene through a G-quadruplex.Oncotarget · 2020Article
- Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis.EMBO molecular medicine · 2020Article
- Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication.Nucleic acids research · 2019Article
- A G-quadruplex motif in an envelope gene promoter regulates transcription and virion secretion in HBV genotype B.Nucleic acids research · 2017Article
- The cellular protein nucleolin preferentially binds long-looped G-quadruplex nucleic acids.Biochimica et biophysica acta. General subjects · 2017Article
- An XIST-related small RNA regulates KRAS G-quadruplex formation beyond X-inactivation.Oncotarget · 2016Article
- NPGPx (GPx7): a novel oxidative stress sensor/transmitter with multiple roles in redox homeostasis.American journal of translational research · 2016Review
- Direct evidence of mitochondrial G-quadruplex DNA by using fluorescent anti-cancer agents.Nucleic acids research · 2015Article
- Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription.Nucleic acids research · 2015Article
- A nucleolin-DNMT1 regulatory axis in acute myeloid leukemogenesis.Oncotarget · 2014Article
- Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers.The Journal of biological chemistry · 2014Article
- U3 region in the HIV-1 genome adopts a G-quadruplex structure in its RNA and DNA sequence.Biochemistry · 2014Article
- Destroy and exploit: catalyzed removal of hydroperoxides from the endoplasmic reticulum.International journal of cell biology · 2013Review
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reported that non-targeting siRNA (NT-siRNA) stress induces non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) expression to cooperate with exoribonuclease XRN2 for releasing the stress [Wei,P.C., Lo,W.T., Su,M.I., Shew,J.Y. and Lee,W.H. (2011) Non-targeting siRNA induces NPGPx expression to cooperate with exoribonuclease XRN2 for releasing the stress. Nucleic Acids Res., 40, 323-332]. However, how NT-siRNA stress inducing NPGPx expression remains elusive. In this communication, we showed that the proximal promoter of NPGPx contained a mixed G-quadruplex (G4) structure, and disrupting the structure diminished NT-siRNA induced NPGPx promoter activity. We also demonstrated that nucleolin (NCL) specifically bonded to the G4-containing sequences to replace the originally bound Sp1 at the NPGPx promoter on NT-siRNA stress. Consistently, overexpression of NCL further increased NPGPx promoter activity, whereas depletion of NCL desensitized NPGPx promoter to NT-siRNA stress. These results suggest that the cis-element with mixed G4 structure at the NPGPx promoter plays an essential role for its transactivation mediated by NCL to release cells from NT-siRNA stress.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.